9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (THA), AN ALLEGED DRUG FOR THE TREATMENT OF ALZHEIMERS-DISEASE, INHIBITS ACETYLCHOLINESTERASE ACTIVITY AND SLOW OUTWARD K+ CURRENT

被引：114

作者：

DRUKARCH, B

KITS, KS

VANDERMEER, EG

LODDER, JC

STOOF, JC

机构：

[1] FREE UNIV AMSTERDAM,FAC MED,DEPT NEUROL,VANDERBOECHORSTSTR 7,1081 BT AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM,DEPT BIOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1987年 / 141卷 / 01期

关键词：

D O I：

10.1016/0014-2999(87)90424-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：153 / 157

页数：5

共 10 条

[1]

BOURDOIS PS, 1974, BRIT J PHARMACOL, V52, P509, DOI 10.1111/j.1476-5381.1974.tb09718.x

[2] THE EFFECTS OF 4-AMINOPYRIDINE AND TETRODOTOXIN ON THE RELEASE OF ACETYLCHOLINE FROM RAT STRIATAL SLICES [J].

DOLEZAL, V ;

TUCEK, S .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1983, 323 (02) :90-95

[3] CHOLINERGIC APPROACHES TO THE TREATMENT OF ALZHEIMERS-DISEASE [J].

HOLLANDER, E ;

MOHS, RC ;

DAVIS, KL .

BRITISH MEDICAL BULLETIN, 1986, 42 (01) :97-100

[4]

KATZMAN R, 1986, NEW ENGL J MED, V315, P1241

[5] ENZYME INHIBITING ACTION OF TETRAHYDROAMINOACRIDINE AND ITS STRUCTURAL FRAGMENTS [J].

KAUL, PN .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1962, 14 (04) :243-&

[6]

KITS KS, IN PRESS MOLLUSCAN M

[7]

RAITERI M, 1984, J PHARMACOL EXP THER, V228, P209

[8] INDEPENDENT INVITRO REGULATION BY THE D-2 DOPAMINE RECEPTOR OF DOPAMINE-STIMULATED EFFLUX OF CYCLIC-AMP AND K+-STIMULATED RELEASE OF ACETYLCHOLINE FROM RAT NEOSTRIATUM [J].

STOOF, JC ;

KEBABIAN, JW .

BRAIN RESEARCH, 1982, 250 (02) :263-270

[9] ORAL TETRAHYDROAMINOACRIDINE IN LONG-TERM TREATMENT OF SENILE DEMENTIA, ALZHEIMER TYPE [J].

SUMMERS, WK ;

MAJOVSKI, LV ;

MARSH, GM ;

TACHIKI, K ;

KLING, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (20) :1241-1245

[10] THA - A REVIEW OF THE LITERATURE AND ITS USE IN TREATMENT OF 5 OVERDOSE PATIENTS [J].

SUMMERS, WK ;

KAUFMAN, KR ;

ALTMAN, F ;

FISCHER, JM .

CLINICAL TOXICOLOGY, 1980, 16 (03) :269-281

← 1 →