SISTER CHROMATID EXCHANGES INDUCED BY INHALED ANESTHETICS

被引:81
作者
WHITE, AE
TAKEHISA, S
EGER, EI
WOLFF, S
STEVENS, WC
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT ANAT,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,RADIOBIOL LAB,SAN FRANCISCO,CA 94143
关键词
D O I
10.1097/00000542-197905000-00010
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
There is sufficient evidence that anesthetics may cause cancer to justify a test of their carcinogenic potential. Baden et al., using the Ames test, a rapid and inexpensive genetic indicator of carcinogenicity, have shown that among currently used anesthetics fluoxene alone caused bacterial mutations. The authors used the sister chromatid exchange (SCE) technique, another rapid assay of mutagenic-carcinogenic potential. The frequency of sister chromatid exchanges in Chinese hamster ovary cells increases when the cell cultures are exposed to mutagen-carcinogens, particularly in the presence of a metabolic activating system. With this test system a one-hour exposure to 1 MAC nitrous oxide, diethyl ether, trichloroethylene, methoxyflurane, enflurane, isoflurane, mryhoxyflurane, or chloroform did not increase SCE values. Divinyl ether, fluroxene and ethyl vinyl ether increased SCE values in the same circumstances. Results of this study of mammalian cells suggest that no currently used anesthetic is a mutagen-carcinogen. The results also suggest that anesthetics containing a vinyl moiety may be mutagen-carcinogens.
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页码:426 / 430
页数:5
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