RABBIT BONE COLLAGENASE INHIBITOR BLOCKS THE ACTIVITY OF OTHER NEUTRAL METALLOPROTEINASES

被引：79

作者：

SELLERS, A

MURPHY, G

MEIKLE, MC

REYNOLDS, JJ

机构：

[1] STRANGEWAYS RES LAB, DEPT CELL PHYSIOL, CAMBRIDGE CB1 4RN, ENGLAND

[2] UCL EASTMAN DENT HOSP, DEPT ORTHODONT, LONDON WC1X 8LD, ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91834-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rabbit bone explants produce a collagenase inhibitor during the first few days in culture and later produce neutral metallo-proteinases, one of which is collagenase. We present evidence that the collagenase inhibitor also blocks the activity of the other neutral metalloproteinases (after activation by 4-amino-phenylmercuric acetate), indicating that one inhibitor may function as a single regulator for all the metalloproteinases involved in connective tisue catabolism. © 1979.

引用

页码：581 / 587

页数：7

共 12 条

[1] PROTEOGLYCAN-DEGRADING ENZYMES - RADIOCHEMICAL ASSAY METHOD AND DETECTION OF A NEW ENZYME, CATHEPSIN-F
DINGLE, JT
BLOW, AMJ
BARRETT, AJ
MARTIN, PEN
[J]. BIOCHEMICAL JOURNAL, 1977, 167 (03) : 775 - 785
[2] DEGRADATION OF CARTILAGE PROTEOGLYCANS BY A NEUTRAL PROTEINASE SECRETED BY RABBIT BONE-MARROW MACROPHAGES IN CULTURE
HAUSER, P
VAES, G
[J]. BIOCHEMICAL JOURNAL, 1978, 172 (02) : 275 - 284
[3] MURPHY G, 1977, BIOCHIM BIOPHYS ACTA, V483, P493, DOI 10.1016/0005-2744(77)90080-8
[4] REYNOLDS JJ, 1977, LANCET, V2, P333
[5] METALLOPROTEASES OF HUMAN ARTICULAR-CARTILAGE THAT DIGEST CARTILAGE PROTEOGLYCAN AT NEUTRAL AND ACID PH
SAPOLSKY, AI
KEISER, H
HOWELL, DS
WOESSNER, JF
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (04) : 1030 - 1041
[6] IDENTIFICATION AND PARTIAL CHARACTERIZATION OF AN INHIBITOR OF COLLAGENASE FROM RABBIT BONE
SELLERS, A
REYNOLDS, JJ
[J]. BIOCHEMICAL JOURNAL, 1977, 167 (02) : 353 - 360
[7] EVIDENCE THAT LATENT COLLAGENASES ARE ENZYME-INHIBITOR COMPLEXES
SELLERS, A
CARTWRIGHT, E
MURPHY, G
REYNOLDS, JJ
[J]. BIOCHEMICAL JOURNAL, 1977, 163 (02) : 303 - 307
[8] SELLERS A, 1978, BIOCHEM J, V171, P439
[9] SIMULTANEOUS RELEASE BY BONE EXPLANTS IN CULTURE AND PARALLEL ACTIVATION OF PROCOLLAGENASE AND OF LATENT NEUTRAL PROTEINASE THAT DEGRADES CARTILAGE PROTEOGLYCANS AND DENATURED COLLAGEN
VAES, G
EECKHOUT, Y
LENAERSCLAEYS, G
FRANCOISGILLET, C
DRUETZ, JE
[J]. BIOCHEMICAL JOURNAL, 1978, 172 (02) : 261 - 274
[10] VAES G, 1978, PERSPECTIVES INFLAMM, P115

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