HALOPERIDOL INDUCES FOS AND RELATED MOLECULES IN INTRASTRIATAL GRAFTS DERIVED FROM FETAL STRIATAL PRIMORDIA

被引：25

作者：

DRAGUNOW, M ^{[1
]}

WILLIAMS, M ^{[1
]}

FAULL, RLM ^{[1
]}

机构：

[1] UNIV AUCKLAND,SCH MED,DEPT ANAT,AUCKLAND,NEW ZEALAND

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 02期

基金：

英国医学研究理事会;

关键词：

Fetal tissue; Fos; Haloperidol; Striatal graft;

D O I：

10.1016/0006-8993(90)91300-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Haloperidol induces Fos and related molecules (Fos-related antigens, FRAs) in adult striatal neurons. We tested whether a similar induction of Fos and FRAs by haloperidol injection would occur in fetal striatal neurons transplanted into adult quinolinic acid-lesioned striatum. We found that Fos and FRAs were induced in striatal neurons after haloperidol. This induction had a time course in transplanted neurons that was identical to the time course of induction in normal adult striatum. Furthermore, the relative numbers of Fos- and FRA-immunopositive neurons induced by haloperidol were identical for both transplanted and normal striatal neurons. These results provide the first demonstration that neurons in intrastriatal grafts derived from fetal striatal primordia have similar intracellular biochemical characteristics to normal adult striatal neurons. © 1990.

引用

页码：309 / 311

页数：3

共 12 条

[1] MECHANISMS OF ACTION OF INTRACEREBRAL NEURAL IMPLANTS - STUDIES ON NIGRAL AND STRIATAL GRAFTS TO THE LESIONED STRIATUM [J].