THE COL6A1 AND COL6A2 GENES EXIST AS A GENE-CLUSTER AND DETECT HIGHLY INFORMATIVE DNA POLYMORPHISMS IN THE TELOMERIC REGION OF HUMAN CHROMOSOME-21Q

被引：31

作者：

FRANCOMANO, CA

CUTTING, GR

MCCORMICK, MK

CHU, ML

TIMPL, R

HONG, HK

ANTONARAKIS, SE

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205

[3] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,JEFFERSON INST MOLEC MED,DEPT BIOCHEM & MOLEC BIOL,PHILADELPHIA,PA 19107

[4] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY

来源：

HUMAN GENETICS | 1991年 / 87卷 / 02期

关键词：

D O I：

10.1007/BF00204174

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genes that encode the alpha 1 (VI) and alpha 2 (VI) collagen chains, designated COL6A1 and COL6A2, map to human chromosomal band 21q22.3. Using pulsed-field gel electrophoresis and somatic cell hybrids, we found that COL6A1 and COL6A2 form a gene cluster on the most distal part of chromosome 21. Furthermore, we detected several DNA polymorphisms (both restriction site and VNTRs) associated with these loci. These polymorphisms make the COL6A1 and COL6A2 genes among the most informative markers on human chromosome 21.

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页码：162 / 166

页数：5

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