THE HYPOLIPIDEMIC ACTIVITY OF HETEROCYCLIC AMINE BORANES IN RODENTS

被引：10

作者：

HALL, IH ^{[1
]}

SOOD, A ^{[1
]}

SPIELVOGEL, BF ^{[1
]}

机构：

[1] BORON BIOL INC,RALEIGH,NC 27607

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1991年 / 45卷 / 08期

关键词：

CHOLESTEROL; TRIGLYCERIDES; LDL CHOLESTEROL; HDL CHOLESTEROL;

D O I：

10.1016/0753-3322(91)90062-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Heterocyclic amine boranes were observed to be potent hypolipidemic agents in rodents at 8 mg/kg per day lowering both serum cholesterol and triglyceride levels. These agents were also effective in lowering tissue lipids. Rat serum lipoprotein cholesterol levels were reduced in the low density lipoprotein (LDL) and very low density lipoprotein (VLDL) fractions and elevated in the high density lipoprotein (HDL) fraction after 14 days. The modes of action of the agents appear to accelerate excretion of lipids in the bile and the suppression of the activities of key hepatic regulatory enzymes of lipids synthesis.

引用

页码：333 / 341

页数：9

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