EFFECTS OF CA-2+ ANTAGONISTS AND ANTIEPILEPTICS ON TETRODOTOXIN-SENSITIVE CA-2+-CONDUCTING CHANNELS IN ISOLATED RAT HIPPOCAMPAL CA1 NEURONS

被引：8

作者：

TAKAHASHI, K ^{[1
]}

KAMEDA, H ^{[1
]}

KATAOKA, M ^{[1
]}

UENO, S ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROPHYSIOL,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 148卷 / 1-2期

关键词：

RAT HIPPOCAMPUS; CA1 PYRAMIDAL NEURON; DISSOCIATED NEURON; TETRODOTOXIN-SENSITIVE CA-2+-CONDUCTING CHANNEL; NA+ CHANNEL; CA-2+ ANTAGONIST; ANTIEPILEPTIC;

D O I：

10.1016/0304-3940(92)90804-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

All Ca2+ antagonists blocked tetrodotoxin-sensitive Ca2+ current (TTX-I(Ca)) more potently than Na+ current (I(Na)). Phenytoin and MK-801, at concentrations which had no effect on I(Na), could block TTX-I(Ca) concentration-dependently. Valproic acid and phenobarbital had no effect on both TTX-I(Ca) and I(Na). In particular. flunarizine and phenytoin have more potent inhibitory effects on TTX-I(Ca) than other test drugs. These results suggest that the abnormal excess-excitation of TTX-sensitive Ca2+-conducting channels may be one of the trigger factors generating epilepsy.

引用

页码：60 / 62

页数：3

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