SPATIAL PATTERN OF RECEPTOR EXPRESSION IN THE OLFACTORY EPITHELIUM

被引：152

作者：

NEF, P ^{[1
]}

HERMANSBORGMEYER, I ^{[1
]}

ARTIERESPIN, H ^{[1
]}

BEASLEY, L ^{[1
]}

DIONNE, VE ^{[1
]}

HEINEMANN, SF ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PHARMACOL,LA JOLLA,CA 92093

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 19期

关键词：

GUANINE NUCLEOTIDE BINDING PROTEIN-COUPLED RECEPTORS; ODOR CODING; OLFACTION; OLFACTORY NEURONS; BILATERAL SYMMETRY;

D O I：

10.1073/pnas.89.19.8948

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A PCR-based strategy for amplifying putative receptors involved in murine olfaction was employed to isolate a member (OR3) of the seven-transmembrane-domain receptor superfamily. During development, the first cells that express OR3 appear adjacent to the wall of the telencephalic vesicle at embryonic day 10. The OR3 receptor is uniquely expressed in a subset of olfactory cells that have a characteristic bilateral symmetry in the adult olfactory epithelium. This receptor and its specific pattern of expression may serve a functional role in odor coding or, alternatively, may play a role in the development of the olfactory system.

引用

页码：8948 / 8952

页数：5

共 28 条

[1] MOLECULAR PHYSIOLOGY OF OLFACTION [J].