INCREASE IN SUBSTANCE-P AND CGRP, BUT NOT SOMATOSTATIN CONTENT OF INNERVATING DORSAL-ROOT GANGLIA IN ADJUVANT MONOARTHRITIS IN THE RAT

被引：109

作者：

SMITH, GD

HARMAR, AJ

MCQUEEN, DS

SECKL, JR

机构：

[1] WESTERN GEN HOSP,DEPT MED,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

[2] MRC,BRAIN METAB UNIT,EDINBURGH,SCOTLAND

[3] DEPT PHARMACOL,EDINBURGH,SCOTLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 02期

基金：

英国惠康基金;

关键词：

ADJUVANT-ARTHRITIS; SUBSTANCE-P; CALCITONIN GENE-RELATED PEPTIDE; SOMATOSTATIN; DORSAL ROOT GANGLIA; INFLAMMATION; CORTICOSTERONE;

D O I：

10.1016/0304-3940(92)90417-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nocioception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204%), but not somatostatin in ipsilateral C6/7 DRG. Peptide levels in contralateral DRG and other ipsilateral DRG were unaltered. Substance P and CGRP in DRG may be of importance in the pathogenesis and maintenance of adjuvant arthritis.

引用

页码：257 / 260

页数：4

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