EFFECTS OF THE 5HT1A AGONIST, 8-OH-DPAT, ON OPERANT FOOD-INTAKE IN NON-DEPRIVED RATS

被引：33

作者：

EBENEZER, IS

机构：

[1] Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, Portsmouth, Hampshire

来源：

NEUROREPORT | 1992年 / 3卷 / 01期

关键词：

8-OH-DPAT; 5-HT; OPERANT BEHAVIOR; FOOD INTAKE; HYPERPHAGIA; 5HT1A RECEPTORS; STEREOTYPY; RATS;

D O I：

10.1097/00001756-199201000-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE aim of the present study was to determine whether the hyperphagia produced by systemic administration of 8-OH-DPAT is independent of drug-induced chewing or gnawing behaviour. The effects of 8-OH-DPAT (15.625-500-mu-g kg-1, s.c.) were therefore investigated on operant food intake in non-deprived rats. Low doses (i.e. 15.625-62.5-mu-g kg-1) increased operant food intake. Drug-induced stereotypy disrupted operant responding at the higher doses. The results thus suggest that 8-OH-DPAT-induced hyperphagia is independent of chewing or gnawing behaviour.

引用

页码：62 / 64

页数：3

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