STRUCTURE OF A CHIRAL BICYCLIC BETA-HYDROXYPHOSPHONAMIDE - AN ASYMMETRIC OLEFINATION INTERMEDIATE, C25H41N2O2P

被引:5
作者
BELANGERGARIEPY, F [1 ]
BENNANI, YL [1 ]
BEAUDOIN, S [1 ]
HANESSIAN, S [1 ]
机构
[1] UNIV MONTREAL,DEPT CHIM,CP 6128,SUCC A,MONTREAL H3C 3J7,QUEBEC,CANADA
关键词
D O I
10.1107/S0108270191014671
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(3aR,7aR)-2,3,3a,4,5,6,7,7a-Octahydro-2-[(R)-alpha-(1-hydroxy-4-tert-butylcyclohexyl)phenyl-methyl]-1,3-dimethyl-1H-1,3,2-benzodiazaphosphole 2-oxide, C25H41N2O2P, M(r) = 432.59, orthorhombic, P2(1)2(1)2(1), a = 10.636 (2), b = 12.759 (1), c = 18.185 (2) angstrom, V = 2467.8 (5) angstrom3, Z = 4, D(x) = 1.164 Mg m-3, lambda(Cu K-alphaBAR) = 1.54178 angstrom, mu = 1.138 mm-1, F(000) = 944, T = 293 K, R = 0.047, wR = 0.039 for 1884) observed reflections. The title compound is constituted of a (1R,2R)-N,N'-dimethyl-1,2-diaminocyclohexane attached to a tetrahedrally coordinated phosphoryl group. A phenylmethyl group with an R configuration bridges the P atom and the 4-tert-butylcyclohexanol ring. The tertiary alcohol is in the axial position and the 4-tert-butyl is in the equatorial position. The molecules are held in the crystal through intermolecular hydrogen bonds of the O-H...O type and by van der Waals interactions.
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页码:1533 / 1535
页数:3
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