SULFONATION IN CHEMICAL CARCINOGENESIS - HISTORY AND PRESENT STATUS

被引：67

作者：

MILLER, JA

机构：

[1] McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1994年 / 92卷 / 1-3期

关键词：

SULFONATION; ELECTROPHILE; NUCLEOPHILE; HEPATOMAS; DNA ADDUCTS;

D O I：

10.1016/0009-2797(94)90074-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many laboratories have characterized the electrophilic metabolites of chemical carcinogens and their covalently bound adducts with genomic DNA in vivo. Recent studies from our laboratory have shown that enzymatic sulfonation of members of several classes of proximate carcinogens containing C- or N-hydroxy groups converts them to electrophilic, mutagenic, and carcinogenic sulfuric acid ester metabolites in mouse liver. These compounds form the subject of this report.

引用

页码：329 / 341

页数：13

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