DOWN-REGULATION OF COLONY-STIMULATING FACTOR-I (CSF-1) BINDING BY CSF-1 IN ISOLATED OSTEOCLASTS

被引:14
作者
AMANO, H
HOFSTETTER, W
CECCHINI, MG
FLEISCH, H
FELIX, R
机构
[1] Department of Pathophysiology, University of Berne, Berne, CH-3010
关键词
COLONY-STIMULATING FACTOR-I; MACROPHAGE COLONY-STIMULATING FACTOR; OSTEOCLAST; BINDING; DOWN-REGULATION;
D O I
10.1007/BF00302072
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Colony-stimulating factor-1 (CSF-1), also called macrophage colony-stimulating factor, is the growth factor for the cells of the mononuclear phagocytic system. Furthermore, CSF-1 is essential in osteoclastogenesis and also affects mature osteoclasts. The receptor for CSF-1 was demonstrated on cells of the osteoclast lineage, with highest levels on the mature cells. This study investigated whether the binding of CSF-1 to isolated rat osteoclasts is modulated by the growth factor itself. Exposure of osteoclasts to CSF-1 for 1 hour virtually abolished binding of the growth factor. After removal of CSF-1, binding sites were restored within 4 hours. This recovery was blocked by cycloheximide, indicating the dependence on new protein synthesis for reexpression of receptors on the cell surface. The observed downregulation of CSF-1 binding sites might be a mechanism to control the effects of the growth factor on mature osteoclasts.
引用
收藏
页码:367 / 370
页数:4
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