HYDROXYLATION OF PROGESTERONE BY CEPHALOSPORIUM-APHIDICOLA

被引：39

作者：

FAROOQ, A

HANSON, JR

IQBAL, Z

机构：

[1] School of Molecular Sciences, University of Sussex, Brighton

来源：

PHYTOCHEMISTRY | 1994年 / 37卷 / 03期

关键词：

CEPHALOSPORIUM APHIDICOLA; PROGESTERONE; 9-BETA; 10-ALPHA-RETROPROGESTERONE; STEROID; MICROBIOLOGICAL HYDROXYLATION;

D O I：

10.1016/S0031-9422(00)90346-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fungus, Cephalosporium aphidicola, has been shown to hydroxylate progesterone predominantly at the 6 beta- and 11 alpha-positions. Minor metabolites include testosterone acetate, the 20(R)-alcohol and 12 beta,17 alpha-dihydroxyprogesterone. The sequence involves hydroxylation at 11 alpha and then 6 beta. The hydroxylations of 11 alpha- and 17 alpha-hydroxyprogesterone and of 9 beta,10 alpha-retroprogesterone have also been examined in the light of these results.

引用

页码：723 / 726

页数：4

共 17 条

[1] STUDIES IN TERPENOID BIOSYNTHESIS .35. BIOSYNTHETIC SEQUENCES LEADING TO THE DITERPENOID APHIDICOLIN IN CEPHALOSPORIUM-APHIDICOLA [J].