ROLIPRAM, A CYCLIC AMP-SELECTIVE PHOSPHODIESTERASE INHIBITOR, REDUCES NEURONAL DAMAGE FOLLOWING CEREBRAL-ISCHEMIA IN THE GERBIL

被引：54

作者：

KATO, H

ARAKI, T

ITOYAMA, Y

KOGURE, K

机构：

[1] FDN BRAIN & NERVE DIS,KUMAGAYA,JAPAN

[2] INST NEUROPATHOL,KUMAGAYA,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 272卷 / 01期

关键词：

CEREBRAL ISCHEMIA; ROLIPRAM; CAMP; PHOSPHODIESTERASE; HIPPOCAMPUS; (GERBIL);

D O I：

10.1016/0014-2999(94)00694-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the effects of rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, on cerebral ischemia-induced neuronal damage in Mongolian gerbils. Transient forebrain ischemia was induced by 3-min occlusion of bilateral common carotid arteries. Rolipram, at a dose of 0.3 or 3 mg/kg, was injected i.p. 30 min before ischemia. Histopathological observations showed that neuronal damage to the hippocampal CA1 subfield, which was seen 7 days after ischemia in vehicle-treated animals, was reduced in animals treated with the higher dose of rolipram.

引用

收藏

页码：107 / 110

页数：4

相关论文

共 15 条

[1] SEQUENTIAL ALTERATION OF [H-3] ROLIPRAM BINDING IN GERBIL BRAIN AFTER TRANSIENT CEREBRAL-ISCHEMIA [J].

ARAKI, T ;

KANAI, Y ;

KATO, H ;

KOGURE, K .

BRAIN RESEARCH BULLETIN, 1993, 31 (1-2) :85-89

[2]

BUCHAN A, 1990, J NEUROSCI, V10, P311

[3] STAUROSPORINE, A NOVEL PROTEIN-KINASE-C INHIBITOR, PREVENTS POSTISCHEMIC NEURONAL DAMAGE IN THE GERBIL AND RAT [J].

HARA, H ;

ONODERA, H ;

YOSHIDOMI, M ;

MATSUDA, Y ;

KOGURE, K .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (05) :646-653

[4] SEQUENTIAL CEREBRAL BLOOD-FLOW CHANGES IN SHORT-TERM CEREBRAL-ISCHEMIA IN GERBILS [J].

KATO, H ;

ARAKI, T ;

KOGURE, K ;

MURAKAMI, M ;

UEMURA, K .

STROKE, 1990, 21 (09) :1346-1349

[5] AUTORADIOGRAPHIC MAPPING OF A SELECTIVE CYCLIC ADENOSINE-MONOPHOSPHATE PHOSPHODIESTERASE IN RAT-BRAIN WITH THE ANTIDEPRESSANT [H-3] ROLIPRAM [J].

KAULEN, P ;

BRUNING, G ;

SCHNEIDER, HH ;

SARTER, M ;

BAUMGARTEN, HG .

BRAIN RESEARCH, 1989, 503 (02) :229-245

[6] A REVERSIBLE TYPE OF NEURONAL INJURY FOLLOWING ISCHEMIA IN THE GERBIL HIPPOCAMPUS [J].

KIRINO, T ;

TAMURA, A ;

SANO, K .

STROKE, 1986, 17 (03) :455-459

[7] DELAYED NEURONAL DEATH IN THE GERBIL HIPPOCAMPUS FOLLOWING ISCHEMIA [J].

KIRINO, T .

BRAIN RESEARCH, 1982, 239 (01) :57-69

[8] CIRCULATING CATECHOLAMINES MODULATE ISCHEMIC BRAIN-DAMAGE [J].

KOIDE, T ;

WIELOCH, TW ;

SIESJO, BK .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1986, 6 (05) :559-565

[9] GLUTAMATE AND THE PATHOPHYSIOLOGY OF HYPOXIC ISCHEMIC BRAIN-DAMAGE [J].

ROTHMAN, SM ;

OLNEY, JW .

ANNALS OF NEUROLOGY, 1986, 19 (02) :105-111

[10] BRAIN CAMP RESPONSE TO PHOSPHODIESTERASE INHIBITORS IN RATS KILLED BY MICROWAVE IRRADIATION OR DECAPITATION [J].

SCHNEIDER, HH .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (10) :1690-1693