THROMBOXANE SYNTHASE INHIBITORS - SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF (R) , (S) , AND (+/-)-2,2-DIMETHYL-6-[2-(1H-IMIDAZOL-1-YL)-1-[[(4-METHOXYPHENYL)-METHOXY]METHYL]ETHOXY]HEXANOIC ACIDS

被引：17

作者：

MANLEY, PW

TUFFIN, DP

ALLANSON, NM

BUCKLE, PE

LAD, N

LAI, SMF

LUNT, DO

PORTER, RA

WADE, PJ

机构：

[1] GD SEARLE & CO LTD,SEARLE RES & DEV,DEPT BIOL,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND

[2] GD SEARLE & CO LTD,SEARLE RES & DEV,DEPT MED CHEM,HIGH WYCOMBE HP12 4HL,BUCKS,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 10期

关键词：

D O I：

10.1021/jm00393a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1812 / 1818

页数：7

共 21 条

[1] PROSTAGLANDINS AND CONGENERS .28. SYNTHESIS OF 2-(OMEGA-CARBALKOXYALKYL)CYCLOPENT-2-EN-1-ONES, INTERMEDIATES FOR PROSTAGLANDIN SYNTHESES [J].

BERNADY, KF ;

POLETTO, JF ;

NOCERA, J ;

MIRANDO, P ;

SCHAUB, RE ;

WEISS, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (23) :4702-4715

[2] SYNTHESIS OF THROMBOXANE-A2 [J].

BHAGWAT, SS ;

HAMANN, PR ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (22) :6372-6376

[3] NOVEL PROSTAGLANDIN SYNTHESES [J].

BUNDY, G ;

LINCOLN, F ;

NELSON, N ;

PIKE, J ;

SCHNEIDER, W .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 180 (APR30) :76-+

[4]

CALDWELL J, 1980, DRUGS PHARM SCI, V10, P211

[5] A THROMBOXANE SYNTHETASE INHIBITOR RE-ORIENTS ENDOPEROXIDE METABOLISM IN WHOLE-BLOOD TOWARDS PROSTACYCLIN AND PROSTAGLANDIN-E2 [J].

DEFREYN, G ;

DECKMYN, H ;

VERMYLEN, J .

THROMBOSIS RESEARCH, 1982, 26 (06) :389-400

[6] PHARMACODYNAMIC AND PHARMACOKINETIC DIFFERENCES BETWEEN DRUG ENANTIOMERS IN HUMANS - AN OVERVIEW [J].

DRAYER, DE .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (02) :125-133

[7] THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998

[8]

HAURAND M, 1985, J BIOL CHEM, V260, P5059

[9] HIGHLY SELECTIVE INHIBITORS OF THROMBOXANE SYNTHETASE .1. IMIDAZOLE DERIVATIVES [J].

IIZUKA, K ;

AKAHANE, K ;

MOMOSE, DI ;

NAKAZAWA, M ;

TANOUCHI, T ;

KAWAMURA, M ;

OHYAMA, I ;

KAJIWARA, I ;

IGUCHI, Y ;

OKADA, T ;

TANIGUCHI, K ;

MIYAMOTO, T ;

HAYASHI, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (10) :1139-1148

[10]

ITO T, 1984, BIOMED BIOCHIM ACTA, V43, pS125

← 1 2 3 →