IDENTIFICATION OF A 3RD ALTERNATIVELY SPLICED CDNA-ENCODING THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 2B-BETA

被引：37

作者：

MCPARTLIN, AE ^{[1
]}

BARKER, HM ^{[1
]}

COHEN, PTW ^{[1
]}

机构：

[1] UNIV DUNDEE, INST MED SCI,DEPT BIOCHEM,MRC, PROT PHOSPHORYLAT UNIT, DUNDEE DD1 4HN, SCOTLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1088卷 / 02期

基金：

英国医学研究理事会;

关键词：

PROTEIN PHOSPHATASE; CDNA SEQUENCE; AMINO ACID SEQUENCE; ISOFORM; ALTERNATIVE SPLICING; (HUMAN);

D O I：

10.1016/0167-4781(91)90069-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA coding for a catalytic subunit of protein phosphatase 2B was isolated from a human teratocarcinoma library. It encodes a third isoform of protein phosphatase 2B-beta, and differs from the cDNA for the second isoform by a deletion of 30 base pairs in the coding region. The deletion results in the loss of ten amino acids between the putative calmodulin site and a postulated autoinhibitory domain. An identical deletion occurs in one of the two alternatively spliced isoforms of PP2B-alpha.

引用

页码：308 / 310

页数：3

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