ROLE OF DORSAL AND MEDIAN RAPHE NUCLEI IN LOWER LIP RETRACTION IN RATS

被引:22
作者
BERENDSEN, HHG
BOURGONDIEN, FGM
BROEKKAMP, CLE
机构
[1] Department of Neuropharmacology, N.V. Organon, NL-5340 BH Oss
关键词
LOWER LIP RETRACTION; DORSAL RAPHE NUCLEUS; MEDIAN RAPHE NUCLEUS; 5-HT1A RECEPTOR AGONIST; 8-OH-DPAT ((+/-)-8-HYDROXY-(DI-N-PROPYLAMINO)TETRALIN); (RAT);
D O I
10.1016/0014-2999(94)90728-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Induction of lower lip retraction after local infusion of the selective 5-HT1A receptor agonist (+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal and median raphe nuclei was measured. Infusion of 8-OH-DPAT (2.5, 5 and 10 mu g/rat) into the median raphe nucleus caused an immediate and dose-dependent lower lip retraction. After infusion into the dorsal raphe nucleus a higher dose was needed. The lowest dose of 8-OH-DPAT that induced lower lip retraction was 10 mu g/rat. Infusion of 8-OH-DPAT (10 mu g/rat) into the pontine reticular nucleus induced the same degree of lower lip retraction as seen after infusion of the compound into the dorsal raphe nucleus. 8-OH-DPAT-induced lower lip retraction was attenuated by s.c. injection of the preferential 5-HT2C receptor agonist m-chlorophenyl-piperazine. The results suggest that lower lip retraction is mediated by 5-HT1A receptors in the median rather than in the dorsal raphe nucleus.
引用
收藏
页码:315 / 318
页数:4
相关论文
共 15 条
[1]   BEHAVIORAL EVIDENCE FOR FUNCTIONAL INTERACTIONS BETWEEN 5-HT-RECEPTOR SUBTYPES IN RATS AND MICE [J].
BERENDSEN, HHG ;
BROEKKAMP, CLE .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (03) :667-673
[2]   SELECTIVE ACTIVATION OF 5HT1A RECEPTORS INDUCES LOWER LIP RETRACTION IN THE RAT [J].
BERENDSEN, HHG ;
JENCK, F ;
BROEKKAMP, CLE .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 33 (04) :821-827
[3]   CARDIOVASCULAR EFFECTS OF 5-HT1A RECEPTOR AGONISTS INJECTED INTO THE DORSAL RAPHE NUCLEUS OF CONSCIOUS RATS [J].
CONNOR, HE ;
HIGGINS, GA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 182 (01) :63-72
[4]   BEHAVIORAL AND BIOCHEMICAL CONSEQUENCES FOLLOWING ACTIVATION OF 5HT1-LIKE AND GABA RECEPTORS IN THE DORSAL RAPHE NUCLEUS OF THE RAT [J].
HIGGINS, GA ;
BRADBURY, AJ ;
JONES, BJ ;
OAKLEY, NR .
NEUROPHARMACOLOGY, 1988, 27 (10) :993-1001
[5]   DIFFERENTIAL BEHAVIORAL ACTIVATION FOLLOWING INTRA-RAPHE INFUSION OF 5-HT1A RECEPTOR AGONISTS [J].
HIGGINS, GA ;
ELLIOTT, PJ .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 193 (03) :351-356
[6]   EFFECTS OF LOCAL APPLICATION OF 5-HT AND 8-OH-DPAT INTO THE DORSAL AND MEDIAN RAPHE NUCLEI ON MOTOR-ACTIVITY IN THE RAT [J].
HILLEGAART, V .
PHYSIOLOGY & BEHAVIOR, 1990, 48 (01) :143-148
[7]   EFFECTS OF LOCAL APPLICATION OF 5-HT AND 8-OH-DPAT INTO THE DORSAL AND MEDIAN RAPHE NUCLEI ON CORE TEMPERATURE IN THE RAT [J].
HILLEGAART, V .
PSYCHOPHARMACOLOGY, 1991, 103 (03) :291-296
[8]   MEDIAN RAPHE, BUT NOT DORSAL RAPHE, APPLICATION OF THE 5-HT1A AGONIST 8-OH-DPAT STIMULATES RAT MOTOR-ACTIVITY [J].
HILLEGAART, V ;
HJORTH, S .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 160 (02) :303-307
[9]   THE SITES OF ORIGIN OF SEROTONINERGIC AFFERENT-FIBERS IN THE TRIGEMINAL MOTOR, FACIAL, AND HYPOGLOSSAL NUCLEI IN THE RAT [J].
LI, YQ ;
TAKADA, M ;
MIZUNO, N .
NEUROSCIENCE RESEARCH, 1993, 17 (04) :307-313
[10]   5-HT(1A)-MEDIATED LOWER LIP RETRACTION - EFFECTS OF 5-HT(1A) AGONISTS AND ANTAGONISTS [J].
MOORE, NA ;
REES, G ;
SANGER, G ;
PERRETT, L .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 46 (01) :141-143