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ROLE OF DORSAL AND MEDIAN RAPHE NUCLEI IN LOWER LIP RETRACTION IN RATS
被引:22
作者:
BERENDSEN, HHG
BOURGONDIEN, FGM
BROEKKAMP, CLE
机构:
[1] Department of Neuropharmacology, N.V. Organon, NL-5340 BH Oss
关键词:
LOWER LIP RETRACTION;
DORSAL RAPHE NUCLEUS;
MEDIAN RAPHE NUCLEUS;
5-HT1A RECEPTOR AGONIST;
8-OH-DPAT ((+/-)-8-HYDROXY-(DI-N-PROPYLAMINO)TETRALIN);
(RAT);
D O I:
10.1016/0014-2999(94)90728-5
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Induction of lower lip retraction after local infusion of the selective 5-HT1A receptor agonist (+)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal and median raphe nuclei was measured. Infusion of 8-OH-DPAT (2.5, 5 and 10 mu g/rat) into the median raphe nucleus caused an immediate and dose-dependent lower lip retraction. After infusion into the dorsal raphe nucleus a higher dose was needed. The lowest dose of 8-OH-DPAT that induced lower lip retraction was 10 mu g/rat. Infusion of 8-OH-DPAT (10 mu g/rat) into the pontine reticular nucleus induced the same degree of lower lip retraction as seen after infusion of the compound into the dorsal raphe nucleus. 8-OH-DPAT-induced lower lip retraction was attenuated by s.c. injection of the preferential 5-HT2C receptor agonist m-chlorophenyl-piperazine. The results suggest that lower lip retraction is mediated by 5-HT1A receptors in the median rather than in the dorsal raphe nucleus.
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页码:315 / 318
页数:4
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