WATER-AVOIDANCE STRESS-INDUCED C-FOS EXPRESSION IN THE RAT-BRAIN AND STIMULATION OF FECAL OUTPUT - ROLE OF CORTICOTROPIN-RELEASING FACTOR

被引:135
作者
BONAZ, B
TACHE, Y
机构
[1] VET ADM WADSWORTH MED CTR,CURE,CTR GASTROENTER BIOL,BLDG 115,ROOM 115,LOS ANGELES,CA 90073
[2] UNIV CALIF LOS ANGELES,DEPT MED,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024
关键词
C-FOS; CRF ANTAGONIST; LOCUS-CERULEUS; PARAVENTRICULAR NUCLEUS OF HYPOTHALAMUS; STRESS; FECAL OUTPUT;
D O I
10.1016/0006-8993(94)91810-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Immunohistochemical detection of the immediate-early gene c-fos was used to determine the pattern of neuronal activity in the rat brain after exposure to water-avoidance stress known to stimulate fecal output in rats. Avoidance to water for 1 h by standing on a small platform increases pellet output and induces numerous Fos-positive cells in the parvocellular part of the paraventricular nucleus of the hypothalamus (PVN), locus coeruleus (LC) and, to a lesser extent, in the bed nucleus of the stria terminalis, lateral septum, dorsal raphe nucleus and A5 and Al noradrenergic neurons. The corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF9-41 (50 mug i.c.v.) reduced water-avoidance stress-induced c-fos expression mainly in the PVN and the LC (44 and 60%, respectively) and decreased by 60% the stimulated fecal output. These data indicate that water-avoidance stress activates PVN and LC neurons through CRF pathways which contribute to the stimulation of colonic motor function.
引用
收藏
页码:21 / 28
页数:8
相关论文
共 49 条
  • [1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS
    ABERCROMBIE, M
    [J]. ANATOMICAL RECORD, 1946, 94 (02): : 239 - 247
  • [2] EXPRESSION OF C-FOS IN REGIONS OF THE BASAL LIMBIC FOREBRAIN FOLLOWING INTRACEREBROVENTRICULAR CORTICOTROPIN-RELEASING FACTOR IN UNSTRESSED OR STRESSED MALE-RATS
    ARNOLD, FJL
    BUENO, MD
    SHIERS, H
    HANCOCK, DC
    EVAN, GI
    HERBERT, J
    [J]. NEUROSCIENCE, 1992, 51 (02) : 377 - 390
  • [3] LOCUS-CERULEUS MODULATES MIGRATING MYOELECTRIC COMPLEX IN RATS
    BONAZ, B
    MARTIN, L
    BEURRIAND, E
    MANIER, M
    HOSTEIN, J
    FEUERSTEIN, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (06): : G1121 - G1126
  • [4] BONAZ B, 1993, GASTROENTEROLOGY, V104, pA815
  • [5] PERIPHERAL BOMBESIN INDUCES C-FOS PROTEIN IN THE RAT-BRAIN
    BONAZ, B
    DEGIORGIO, R
    TACHE, Y
    [J]. BRAIN RESEARCH, 1993, 600 (02) : 353 - 357
  • [6] BONAZ B, 1993, GASTROENTEROLOGY, V104, pA479
  • [7] CNS VASOPRESSIN MEDIATES EMOTIONAL-STRESS AND CRH-INDUCED COLONIC MOTOR ALTERATIONS IN RATS
    BUENO, L
    GUE, M
    DELRIO, C
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (03): : G427 - G431
  • [8] RESTRAINT AND STIMULATION OF BED NUCLEUS OF THE STRIA TERMINALIS PRODUCE SIMILAR STRESS-LIKE BEHAVIORS
    CASADA, JH
    DAFNY, N
    [J]. BRAIN RESEARCH BULLETIN, 1991, 27 (02) : 207 - 212
  • [9] EVIDENCE FOR 2 DIFFERENT AFFERENT PATHWAYS CARRYING STRESS-RELATED INFORMATION (NOXIOUS AND AMYGDALA STIMULATION) TO THE BED NUCLEUS OF THE STRIA TERMINALIS
    CASADA, JH
    DAFNY, N
    [J]. BRAIN RESEARCH, 1992, 579 (01) : 93 - 98
  • [10] EXPRESSION OF C-FOS IMMUNOREACTIVITY IN TRANSMITTER-CHARACTERIZED NEURONS AFTER STRESS
    CECCATELLI, S
    VILLAR, MJ
    GOLDSTEIN, M
    HOKFELT, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) : 9569 - 9573