STRUCTURAL CHARACTERIZATION OF GLUTAMINERGIC BLOCKER SPIDER TOXINS BY HIGH-ENERGY COLLISION CHARGE-REMOTE FRAGMENTATIONS

被引：13

作者：

FUJITA, T

ITAGAKI, Y

NAOKI, H

NAKAJIMA, T

HAGIWARA, K

机构：

[1] SUNTORY LTD,INST BIOORGAN RES,SHIMAMOTO,OSAKA 618,JAPAN

[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1995年 / 9卷 / 05期

关键词：

D O I：

10.1002/rcm.1290090502

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Spider venom gland stores various glutaminergic blockers such as acylpolyamines, besides proteins: and peptides. A method is described for structure determination of these acylpolyamines using fast-atom bombardment and four-sector tandem mass spectrometry. The collision-induced dissociation (CID) spectra of protonated molecular ions of synthetic model compounds show only a small number of weak, sequence-related product ions. But, unlike the CID spectra of [M+H](+) ions, dissociation of sodium-attached molecular ions leads to charge-remote fragmentations and provides intense sequence-related product ions.

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页码：365 / 371

页数：7

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