SEIZURE AFTER ISOLATED FLUOXETINE OVERDOSE

被引：22

作者：

BRAITBERG, G

CURRY, SC

机构：

来源：

ANNALS OF EMERGENCY MEDICINE | 1995年 / 26卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(95)70157-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Previous case reports of seizures following fluoxetine overdose have not adequately ruled out ingestion of other substances and have lacked documentation of increased serum drug levels. We present a case of seizure following fluoxetine overdose in a previously well patient with a clear history of sole ingestion. We ruled out the presence of other substances with comprehensive drug screening and documented increased serum levels of fluoxetine and its active metabolite.

引用

页码：234 / 237

页数：4

共 20 条

[1]

Cooper, The safety of fluoxetine: An update, Br J Psychiatr, 153, pp. 77-86, (1988)

[2]

Wernicke, The side effect profile and safety of fluoxetine, J Clin Psychiatr, 46, 2 sec, pp. 59-67, (1985)

[3]

Mills, Serotonin toxicity: A comprehensive review for emergency medicine, Top Emerg Med, 15, pp. 54-73, (1993)

[4]

Stark, Fuller, Tong, The pharmacologic profile of fluoxetine, J Clin Psychiatr, 46, 2 sec, pp. 7-13, (1985)

[5]

Lemberger, Bergstrom, Wolren, Et al., Fluoxetine: Clinical pharmacology and physiologic disposition, J Clin Psychiatr, 46, 2 sec, pp. 14-19, (1985)

[6]

Buterbaugh, Effect of drugs modifying central serotonergic function on the extensor and non extensor rats to maximal electroshock, Life Sci, 23, pp. 2393-2404, (1978)

[7]

Yan, Jobe, Dailey, Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats, European Journal of Pharmacology, 252, pp. 105-112, (1994)

[8]

Prendiville, Gale, Anticonvulsant effect of fluoxetine on focally evoked limb motor seizures in rats, Epilepsia, 34, pp. 381-384, (1993)

[9]

Leander, Fluoxetine, a selective serotonin-uptake inhibitor, enhances the anticonvulsant effects of phenytoin, carbamazepine and ameltolide, Epilepsia, 33, pp. 573-576, (1992)

[10]

Ware, Stewart, Seizures associated with fluoxetine therapy, DICP Ann Pharmacother, 23, (1989)

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