Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

被引：91

作者：

Lin, MW

Curtis, D

Williams, N

Arranz, M

Nanko, S

Collier, D

McGuffin, P

Murray, R

Owen, M

Gill, M

Powell, J

机构：

[1] INST PSYCHIAT,DEPT NEUROSCI,LONDON SE5 8AF,ENGLAND

[2] INST PSYCHIAT,DEPT PSYCHOL MED,LONDON SE5 8AF,ENGLAND

[3] UNIV WALES COLL MED,DEPT PSYCHOL MED,CARDIFF CF4 4XN,S GLAM,WALES

[4] TEIKYO UNIV,SCH MED,DEPT PSYCHIAT,TOKYO 173,JAPAN

[5] ST JAMES HOSP,TRINITY CTR HLTH SCI,DEPT PSYCHIAT,DUBLIN,IRELAND

来源：

PSYCHIATRIC GENETICS | 1995年 / 5卷 / 03期

关键词：

chromosome; 13; heterogeneity; linkage analysis; schizophrenia;

D O I：

10.1097/00041444-199505030-00004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13, A lod2 score of 1.61 for marker D13S144 was obtained at theta = 0 and alpha of 0.5 and nearby markers also produced positive values.

引用

页码：117 / 126

页数：10

共 23 条

[1] ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE [J].

ARRANZ, M ;

COLLIER, D ;

SODHI, M ;

BALL, D ;

ROBERTS, G ;

PRICE, J ;

SHAM, P ;

KERWIN, R .

LANCET, 1995, 346 (8970) :281-282

[2]

BARR CL, 1994, AM J MED GENET, V45, P51

[3] DOLINK - A COMPUTER-PROGRAM TO FACILITATE MANAGEMENT OF GENETIC DATA AND ANALYSES [J].

COOK, CCH ;

GURLING, HMD ;

CURTIS, D .

ANNALS OF HUMAN GENETICS, 1993, 57 :307-310

[4] GENOMIC SCAN FOR GENES PREDISPOSING TO SCHIZOPHRENIA [J].

COON, H ;

JENSEN, S ;

HOLIK, J ;

HOFF, M ;

MYLESWORSLEY, M ;

REIMHERR, F ;

WENDER, P ;

WALDO, M ;

FREEDMAN, R ;

LEPPERT, M ;

BYERLEY, W .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1994, 54 (01) :59-71

[5] A PROCEDURE FOR COMBINING 2-POINT LOD SCORES INTO A SUMMARY MULTIPOINT MAP [J].

CURTIS, D ;

GURLING, H .

HUMAN HEREDITY, 1993, 43 (03) :173-185

[6]

DAWSON E, 1993, SCHIZOPHR RES, V9, P116

[7] A LINKAGE STUDY OF SCHIZOPHRENIA WITH DNA MARKERS FROM THE LONG ARM OF CHROMOSOME-11 [J].

GILL, M ;

MCGUFFIN, P ;

PARFITT, E ;

MANT, R ;

ASHERSON, P ;

COLLIER, D ;

VALLADA, H ;

POWELL, J ;

SHAIKH, S ;

TAYLOR, C ;

SARGEANT, M ;

CLEMENTS, A ;

NANKO, S ;

TAKAZAWA, N ;

LLEWELLYN, D ;

WILLIAMS, J ;

WHATLEY, S ;

MURRAY, R ;

OWEN, M .

PSYCHOLOGICAL MEDICINE, 1993, 23 (01) :27-44

[8]

GOTTESMAN II, 1991, SCHIZOPHRENIA GENETI

[9] THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].

GYAPAY, G ;

MORISSETTE, J ;

VIGNAL, A ;

DIB, C ;

FIZAMES, C ;

MILLASSEAU, P ;

MARC, S ;

BERNARDI, G ;

LATHROP, M ;

WEISSENBACH, J .

NATURE GENETICS, 1994, 7 (02) :246-339

[10] REPORT FROM THE MARYLAND EPIDEMIOLOGY SCHIZOPHRENIA LINKAGE STUDY - NO EVIDENCE FOR LINKAGE BETWEEN SCHIZOPHRENIA AND A NUMBER OF CANDIDATE AND OTHER GENOMIC REGIONS USING A COMPLEX DOMINANT MODEL [J].

KARAYIORGOU, M ;

KASCH, L ;

LASSETER, VK ;

HWANG, J ;

ELANGO, R ;

BERNARDINI, DJ ;

KIMBERLAND, M ;

BABB, R ;

FRANCOMANO, CA ;

WOLYNIEC, PS ;

LAMACZ, M ;

NESTADT, G ;

MEYERS, D ;

OTT, J ;

CHILDS, B ;

ANTONARAKIS, S ;

KAZAZIAN, HH ;

HOUSMAN, DE ;

PULVER, AE .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1994, 54 (04) :345-353

← 1 2 3 →