HEMICHOLINIUM-3 - NONCHOLINERGIC EFFECTS ON SQUID AXONS

被引：13

作者：

FRAZIER, DT

NARAHASHI, T

MOORE, JW

机构：

[1] Department of Physiology, University of New Mexico, School of Medicine, Albuquerque

[2] Department of Physiology and Pharmacology, Duke University Medical Center, Durham

来源：

SCIENCE | 1969年 / 163卷 / 3869期

关键词：

D O I：

10.1126/science.163.3869.820

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hemicholinium-3, when applied to the inside of a squid axon, is effective in blocking the action potential. This action is not antagonized by the addition of choline or acetylcholine to the perfusate. Voltage-clamp experiments show that hemicholinium-3 depresses both the early transient and late steady-state components of membrane ionic conductances, with a greater effect on the peak transient component.

引用

页码：820 / +

页数：1

共 9 条

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