BIOCHEMICAL-STUDY ON THE HYPOTENSIVE EFFECT OF BERBERINE IN RATS

被引：48

作者：

CHUN, YT ^{[1
]}

YIP, TT ^{[1
]}

LAU, KL ^{[1
]}

KONG, YC ^{[1
]}

SANKAWA, U ^{[1
]}

机构：

[1] UNIV TOKYO,SCH PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

GENERAL PHARMACOLOGY | 1979年 / 10卷 / 03期

关键词：

D O I：

10.1016/0306-3623(79)90085-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. Intravenous infusion of berberine to rats lowered the blood pressure in a dose-dependent manner and a significant hypotensive effect was followed by bradycardia. These effects were also observed in bilaterally vagotomized rats. 2. 2. Berberine further lowered the blood pressure in rats under maximal blockage by pentolinium. 3. 3. Berberine inhibited rat auricular cholinesterase. The inhibition on true acetylcholinesterase was found to be more pronounced than on non-specific cholinesterase. This inhibition process may contribute to the hypotensive action of berberine. 4. 4. The above observations indicate that the hypotensive effect of berberine may involve the heart performance. © 1979.

引用

页码：177 / 182

页数：6

共 13 条

[1] THE CHOLINESTERASES OF HUMAN BLOOD .2. THE FORCES ACTING BETWEEN ENZYME AND SUBSTRATE
ADAMS, DH
WHITTAKER, VP
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1950, 4 (04) : 543 - 558
[2] Antopol W, 1939, P SOC EXP BIOL MED, V42, P280
[3] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY
ELLMAN, GL
COURTNEY, KD
ANDRES, V
FEATHERSTONE, RM
[J]. BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) : 88 - &
[4] FUKUDA H, 1970, CHEM PHARM BULL, V18, P1299
[5] HANO K, 1960, YAKUGAKU KENKYU, V32, P836
[6] Jang C, 1941, J PHARMACOL EXP THER, V71, P178
[7] JANG CS, 1953, ACTA PHARMACOL SINIC, V19, P12
[8] MOLECULAR-SPECIES OF ACETYLCHOLINESTERASE IN DENERVATED RAT SKELETAL-MUSCLE
MCLAUGHLIN, J
BOSMANN, HB
[J]. EXPERIMENTAL NEUROLOGY, 1976, 52 (02) : 263 - 271
[9] THE DISTRIBUTION OF CHOLINESTERASE TYPES IN MAMMALIAN TISSUES
ORD, MG
THOMPSON, RHS
[J]. BIOCHEMICAL JOURNAL, 1950, 46 (03) : 346 - 352
[10] STUDIES ON DISTRIBUTION OF CHOLINESTERASES - ACTIVITY IN HUMAN AND DOG HEART
SINHA, SN
KERESZTESNAGY, S
FRANKFATER, A
[J]. PEDIATRIC RESEARCH, 1976, 10 (08) : 754 - 758

← 1 2 →