ONE-POT SYNTHESIS OF N-(2-HETEROARYL)-ALPHA-AMINO ESTERS BY THE REGIOSPECIFIC 2-N-(ALPHA-ALKOXYCARBONYL)ALKYLATION OF 2-AMINOAZINES AND 2-AMINOAZOLES WITH GLYOXALS AND ALCOHOLS PROMOTED BY PERCHLORIC-ACID

被引：12

作者：

ALCAIDE, B

PLUMET, J

SIERRA, MA

机构：

[1] Departamento de Quimica Organica I, Facultad de Quimica, Universidad Complutense

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 10期

关键词：

D O I：

10.1021/jo00297a033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Amino heterocycles, including pyridine, diazine, andd azole derivatives, are readily converted into N-(2-heteroaryl)-α-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid. In addition, the corresponding a-amino acids 5 are quantitatively obtained by acidic hydrolysis of compounds 4. © 1990, American Chemical Society. All rights reserved.

引用

页码：3143 / 3147

页数：5

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