ONE-POT SYNTHESIS OF N-(2-HETEROARYL)-ALPHA-AMINO ESTERS BY THE REGIOSPECIFIC 2-N-(ALPHA-ALKOXYCARBONYL)ALKYLATION OF 2-AMINOAZINES AND 2-AMINOAZOLES WITH GLYOXALS AND ALCOHOLS PROMOTED BY PERCHLORIC-ACID

被引:12
作者
ALCAIDE, B
PLUMET, J
SIERRA, MA
机构
[1] Departamento de Quimica Organica I, Facultad de Quimica, Universidad Complutense
关键词
D O I
10.1021/jo00297a033
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
2-Amino heterocycles, including pyridine, diazine, andd azole derivatives, are readily converted into N-(2-heteroaryl)-α-amino esters 4 in a one-pot sequence by reaction with glyoxals and alcohols in the presence of perchloric acid. In addition, the corresponding a-amino acids 5 are quantitatively obtained by acidic hydrolysis of compounds 4. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:3143 / 3147
页数:5
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