ATHEROSCLEROSIS AND MOLECULAR PATHOLOGY - MECHANISMS OF CHOLESTERYL ESTER ACCUMULATION IN FOAM CELLS AND EXTRACELLULAR-SPACE OF ATHEROSCLEROTIC LESIONS

被引：14

作者：

TAKANO, T

MINEO, C

机构：

[1] Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01, Sagamiko

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 07期

关键词：

atherosclerosis; cholesteryl ester; endothelial cell; extracellular space; foam cell; lipoprotein; monoclonal antibody; peroxidized lipoprotein; transcytosis;

D O I：

10.1248/bpb1978.13.385

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article reviews aspects of the molecular pathology of cholesteryl ester accumulation in atherosclerotic lesions. 1. Transcytosis of lipoproteins through cultured endothelial monolayer. 2. Transformation to foam cell from macrophage. 3. Cholesteryl ester deposition in the extracellular space of atherosclerotic lesions. We also discuss the development and use of novel monoclonal antibodies recognizing atherosclerotic lesions and peroxidized lipoproteins prepared from atherosclerotic lesions. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：385 / 413

页数：29

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