CIGARETTE-SMOKING AND OUTCOMES OF INVITRO FERTILIZATION AND EMBRYO TRANSFER - A PROSPECTIVE COHORT STUDY

被引：33

作者：

HUGHES, EG

YOUNGLAI, EV

WARD, SM

机构：

[1] Department of Obstetrics and Gynaecology, McMaster University, Hamilton, ON, L8N 3Z5

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 03期

关键词：

EMBRYO; INVITRO FERTILIZATION; SOCIOECONOMIC FACTORS; SMOKING; TOXICOLOGY;

D O I：

10.1093/oxfordjournals.humrep.a137650

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A prospective cohort study of 222 consecutive couples undergoing 297 cycles of in-vitro fertilization and embryo transfer (IVF - ET) was conducted to evaluate the impact of cigarette smoking in males and females. Compared with non-smokers, females smoking at the time of treatment had more Previous pregnancies (1.16 versus 0.63, P < 0.001), consumed more coffee per day (3.29 versus 1.85 cups, P = 0.001) and were less likely to hold a professional or skilled job (41% versus 66%). There was no difference in the response to ovarian stimulation in terms of the duration and dose of human menopausal gonadotrophin, peak oestradiol level or number of oocytes retrieved. The fertilization rate was actually higher in heavy smokers than in non-smokers (79.3% versus 61.3%, P = 0.007). The rate of embryo cleavage was retarded in a dose-dependent fashion. In smokers of 1-14 cigarettes/day, the likelihood of transferring an embryo at greater-than-or-equal-to 4-cell stage was 0.87 [95% confidence limits (CL) 0.56 - 1.4] and in smokers of greater-than-or-equal-to 15 cigarettes/day, the likelihood was 0.52 (95% CL 0.31-0.88). However, evaluation of interrelated factors using logistic regression suggested that a low socioeconomic status had a greater detrimental effect on embryo cleavage rate than female smoking. No significant difference was noted in the clinical outcome following embryo transfer. A study of larger sample size is required to evaluate whether the effects of cigarette smoking are independent of socioeconomic status and other related factors and whether they result in reduced ongoing clinical pregnancy and live birth rates.

引用

页码：358 / 361

页数：4

共 15 条

[1]

Baird D.D., Wilcox A.J., Cigarette smoking associated with delayed conception, J. Am. Med. Assoc, 253, pp. 2979-2983, (1985)

[2]

Claman P., Armant D.R., Seibel M.M., Wang T.A., Oskowitz S.P., Taymore M.L., The impact of embryo quality and quantity on implantation and the establishment of viable pregnancies, J. In Vitro Fertil. Embryo Transfer, 4, pp. 218-222, (1987)

[3]

Cramer D.W., Schiff I., Schoenbaum S.C., Gibson M., Belisle S., Albrecht B., Stillman R.J., Berger M.J., Wilson E., Stadel B.V., Seibel M., Tubal infertility and the intrauterine device, New Engl, J. Med, 312, pp. 941-947, (1985)

[4]

Cummins J.M., Breen T.M., Harrison K.L., Shaw J.M., Wilson L.M., Hennessey J.F., A formula for scoring human embryo growth rates in in vitro fertilization: Its value in predicting pregnancy and in comparison with visual estimates of embryo quality, J. In Vitro Fertil. Embryo Transfer, 3, pp. 284-295, (1986)

[5]

Daling J.R., Weiss N.S., Metch B.J., Chow W.H., Soderstrom R.M., Moore D.E., Spadoni L.R., Stadel B.V., Primary tubal infertility in relation to the use of an intrauterine device, New Engl, J. Med, 312, pp. 937-941, (1985)

[6]

Elenbogen A., Lipitz S., Mashiach S., Dor J., Levran D., Ben-Rafael Z., The effect of smoking on the outcome of in-vitro fertilization-embryo transfer, Hum. Reprod, 6, pp. 242-244, (1991)

[7]

Harrison K.L., Breen T.M., Hennessey J.F., The effect of patient smoking habit on the outcome of IVF and GIFT treatment, Aust. NZ J. Obstet. Gynaecol, 30, pp. 340-343, (1990)

[8]

Howe G., Westhoff C., Vessey M., Yeates D., Effects of age, cigarette smoking, and other factors on fertility: Findings in a large prospective study, Br. Med, J, 290, pp. 1697-1700, (1985)

[9]

Olsen J., Rachootin P., Schiodt A.V., Damsbo N., Tobacco use, alcohol consumption and infertility, Int, J. Epidemiol, 12, pp. 179-184, (1983)

[10]

Pattinson H.A., Taylor P.J., Pattinson M.H., The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment, Fertil. Steril, 55, pp. 780-783, (1991)

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