GENETIC EPIDEMIOLOGY OF COMPLEX PHENOTYPES

被引：59

作者：

MORTON, NE

SHIELDS, DC

COLLINS, A

机构：

[1] GRC Research Group in Genetic Epidemiology, Southampton General Hospital, Southampton, SO9 4XY, South Academic Block

来源：

ANNALS OF HUMAN GENETICS | 1991年 / 55卷

关键词：

D O I：

10.1111/j.1469-1809.1991.tb00857.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A theory is given for complex phenotypes represented by an ordered polychotomy separately for affected (as severity) and for normals (as diathesis), with consideration of history, ascertainment, sampling frames, and phenotype systems. Nonrandom selection of probands by severity is permitted. Both probit and logistic models are developed in a form compatible with segregation and/or linkage analysis. Probabilities are set out in detail in the Appendix. This approach avoids problems that have been encountered with quantitative traits and correlated phenotypes, although using this information.

引用

页码：301 / 314

页数：14

共 39 条

[1]

Agresti A., 1984, ANAL ORDINAL CATEGOR

[2] ORDINAL REGRESSION-MODELS FOR EPIDEMIOLOGIC DATA [J].

ARMSTRONG, BG ;

SLOAN, M .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (01) :191-204

[3]

BARBUJANI G, 1990, HUM GENET, V84, P522

[4]

BOEHNKE M, 1984, AM J HUM GENET, V36, P1298

[5] DISEASES HAVING 2 CLASSES OF SEVERITY - ESTIMATION OF THE PROPORTIONS OF EACH MANIFESTATION BY MAXIMUM-LIKELIHOOD [J].

BONAITI, C ;

DEMENAIS, F .

BIOMETRICS, 1980, 36 (03) :447-460

[6] REGRESSIVE LOGISTIC-MODELS FOR ORDERED AND UNORDERED POLYCHOTOMOUS TRAITS - APPLICATION TO AFFECTIVE-DISORDERS [J].

BONNEY, GE ;

DUNSTON, GM ;

WILSON, J .

GENETIC EPIDEMIOLOGY, 1989, 6 (01) :211-215

[7] REGRESSIVE LOGISTIC-MODELS FOR FAMILIAL DISEASE AND OTHER BINARY TRAITS [J].

BONNEY, GE .

BIOMETRICS, 1986, 42 (03) :611-625

[8] GENETIC ETIOLOGY OF GASTRIC-CARCINOMA .1. CHRONIC ATROPHIC GASTRITIS [J].

BONNEY, GE ;

ELSTON, RC ;

CORREA, P ;

HAENSZEL, W ;

ZAVALA, DE ;

ZARAMA, G ;

COLLAZOS, T ;

CUELLO, C .

GENETIC EPIDEMIOLOGY, 1986, 3 (04) :213-224

[9] RELATIVES OF PROBANDS - MODELS FOR PRELIMINARY GENETIC ANALYSIS [J].

CAMPBELL, MA ;

ELSTON, RC .

ANNALS OF HUMAN GENETICS, 1971, 35 (OCT) :225-&

[10]

CANNINGS C, 1977, CLIN GENET, V12, P208

← 1 2 3 4 →