POSTTRANSFUSIONAL ANTI-HCV-NEGATIVE NON-A-HEPATITIS NON-B-HEPATITIS .2. SEROLOGICAL AND POLYMERASE CHAIN-REACTION ANALYSIS FOR HEPATITIS-C AND HEPATITIS-B VIRUSES

被引:32
作者
THIERS, V
LUNEL, F
VALLA, D
AZAR, N
FRETZ, C
FRANGEUL, L
HURAUX, JM
OPOLON, P
BRECHOT, C
机构
[1] CHU NECKER,INSERM U75,141-161 RUE SEVRES,F-75743 PARIS 15,FRANCE
[2] INST PASTEUR,F-75724 PARIS 15,FRANCE
[3] GRP HOSP PITIE SALPETRIERE,VIROL LAB,F-75634 PARIS 13,FRANCE
[4] GRP HOSP PITIE SALPETRIERE,CTR TRANSFUS SANGUINE,F-75634 PARIS 13,FRANCE
[5] GRP HOSP PITIE SALPETRIERE,SERV HEPATOGASTROENTEROL,F-75634 PARIS 13,FRANCE
[6] HOP NECKER ENFANTS MALAD,UNITE HEPATOL,F-75730 PARIS 15,FRANCE
关键词
TRANSFUSION; NON-A-HEPATITIS; NON-B-HEPATITIS; HCV; HHV6; HEV; POLYMERASE CHAIN REACTION;
D O I
10.1016/S0168-8278(05)80007-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatitis C virus (HCV) is a major etilogical agent of post-transfusional and sporadic acute and chronic hepatitis in various geographical areas. However, anti-HCV seroconversion was uncommon in a recent study of patients with post-transfusional hepatitis in Paris, France (N. Asar et al., companion paper). The aim of the present study was to detect viral markers, in particular HCV RNA and hepatitis B virus (HBV) DNA, in these patients. A combination of second-generation assays for anti-HCV antibodies and the polymerase chain reaction were used to identify HCV RNA and HBV DNA sequences in serum samples collected before and after transfusion from patients who developed non-A, non-B hepatitis. Eighteen cases of acute, post-transfusional, non-A, non-B hepatitis were identified in the prospective clinical survey. Only three of these 18 subjects developed anti-HCV antibodies in second-generation tests. HCV RNA was identified in the serum of these three subjects but in none of the others. Two patients who were anti-HCV-negative had polymerase chain reaction evidence of HBV DNA. Known viral markers were not identified in 13 of the 18 patients with acute post-transfusional non-A, non-B hepatitis. These results raise the issue of HCV strains or 'non-A, non-B, non-C' viruses not identified by current HCV and HBV markers and implicated in post-transfusional hepatitis in France.
引用
收藏
页码:34 / 39
页数:6
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