VERTEBRATE (CHICK) COLLAGEN FIBRILS FORMED IN-VIVO CAN EXHIBIT A REVERSAL IN MOLECULAR POLARITY

被引:39
作者
HOLMES, DF [1 ]
LOWE, MP [1 ]
CHAPMAN, JA [1 ]
机构
[1] UNIV MANCHESTER,DEPT BIOCHEM MOLEC BIOL,MANCHESTER M13 9PT,LANCS,ENGLAND
基金
英国惠康基金;
关键词
COLLAGEN FIBRILS; POLARITY REVERSAL IN COLLAGEN; ANTIPARALLEL COLLAGEN MOLECULES; ISOLATION OF COLLAGEN FIBRILS;
D O I
10.1016/S0022-2836(05)80016-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A reversal in molecular polarity can occur in vertebrate collagen fibrils. This has been demonstrated using a method for isolating, from chick embryo tendon, entire collagen fibrils 2 to 14 μm in length and suitable for electron-optical examination. A polarity reversal is present in some, but not all, of these fibrils. Such fibrils have two N-ends. The transition region, occupying several D-periods in which the reversal occurs, is not restricted to a central location in a fibril. Analysis of the fibril banding pattern through the transition region shows that the relative axial alignment of antiparallel molecules brings oppositely-directed C-telopeptides into axial register. This could allow antiparallel molecules to be covalently linked via polymeric cross-links involving these C-telopeptides. © 1994 Academic Press Limited.
引用
收藏
页码:80 / 83
页数:4
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