EVALUATION OF PALPABLE BREAST MASSES WITH TC-99M-MIBI - A COMPARATIVE-STUDY WITH MAMMOGRAPHY AND ULTRASONOGRAPHY

被引:93
作者
BURAK, Z
ARGON, M
MEMIS, A
ERDEM, S
BALKAN, Z
DUMAN, Y
USTUN, EE
ERHAN, Y
OZKILIC, H
机构
[1] AEGEAN UNIV, DEPT RADIOL, BORNOVA, TURKEY
[2] AEGEAN UNIV, DEPT PATHOL, BORNOVA, TURKEY
关键词
D O I
10.1097/00006231-199408000-00005
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
We evaluated the feasibility of Tc-99m-methoxyisobutylisonitrile (MIBI) as a tumour localizing agent in patients with palpable breast masses in comparison with mammography and ultrasonography (US). Forty-one patients with palpable masses were studied. An additional 12 women with no palpable breast anomaly also underwent Tc-99m-MIBI breast study. Multiple views were obtained and semiquantitative evaluation was applied. Mammography and US revealed all of the malignant breast masses but differential diagnosis of fibroadenomas could not be achieved. Twenty-five of 27 breast carcinomas were detected using Tc-99m-MIBI scintigraphy. Two patients with invasive lobular carcinoma showed absent MIBI accumulation. Eight of 14 axillary lymph-node metastases showed positive uptake (57%). Twelve of 14 patients with pathologically proven benign breast lesions did not demonstrate any MIBI accumulation. Focal MIBI uptake could be observed in two fibroadenomas. The sensitivity and the specificity of semiquantitative MIBI analysis were 93 and 86%, respectively. Subjective grading offered no additional help in the further differentiation of malignant breast masses. There was no significant difference between histopathological types of breast carcinomas and uptake grades. Our results indicate that Tc-99m-MIBI scintigraphy may provide additional information in the differentiation of malignant pathologies from benign lesions in patients with palpable breast anomalies.
引用
收藏
页码:604 / 612
页数:9
相关论文
共 53 条
[1]   INVASIVE LOBULAR CARCINOMA - MAMMOGRAPHIC PATTERN [J].
ADLER, OB ;
ENGEL, A .
FORTSCHRITTE AUF DEM GEBIETE DER RONTGENSTRAHLEN UND DER NEUEN BILDGEBENDEN VERFAHREN, 1990, 152 (04) :460-462
[2]  
ATKINS HL, 1977, J NUCL MED, V18, P133
[3]   THE ROLE OF GA-67 IN THE CLINICAL-EVALUATION OF CANCER [J].
BEKERMAN, C ;
HOFFER, PB ;
BITRAN, JD .
SEMINARS IN NUCLEAR MEDICINE, 1984, 14 (04) :296-323
[4]  
BEUGLET CC, 1983, AM J RADIOL, V140, P369
[5]  
BOHMVELEZ M, 1976, RADIOLOGY, V118, P425
[6]   THALLIUM ACTIVATION OF (NA+-K+)-ACTIVATED ATPASE OF RABBIT KIDNEY [J].
BRITTEN, JS ;
BLANK, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 159 (01) :160-&
[7]  
CARVALHO PA, 1992, J NUCL MED, V33, P1516
[8]   THALLIUM-201 CHLORIDE UPTAKE IN TUMORS, A POSSIBLE COMPLICATION IN HEART SCINTIGRAPHY [J].
COX, PH ;
BELFER, AJ ;
VANDERPOMPE, WB .
BRITISH JOURNAL OF RADIOLOGY, 1976, 49 (585) :767-768
[9]  
DELMONMOINGEON LI, 1990, CANCER RES, V50, P2198
[10]   THE VALUE AND LIMITATIONS OF TL-201 SCINTIGRAPHY IN THE EVALUATION OF LUNG LESIONS AND POST-THERAPY FOLLOW-UP OF PRIMARY LUNG-CARCINOMA [J].
DUMAN, Y ;
BURAK, Z ;
ERDEM, S ;
TUFAN, M ;
UNLU, M ;
HAYDAROGULLARI, A ;
OZKOK, S ;
ANACAK, Y ;
ERDINC, E .
NUCLEAR MEDICINE COMMUNICATIONS, 1993, 14 (06) :446-453