RING CLOSURE REACTIONS WITH NITRILES .2. FORMATION OF PYRROLO[1,2-A]QUINAZOLINES AND THIAZOLO[3,2-A]QUINAZOLINES

被引：10

作者：

BELL, SC

WEI, PHL

机构：

[1] Research Division, Wyeth Laboratories, Inc., Radnor, Pennsylvania

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1968年 / 5卷 / 02期

关键词：

D O I：

10.1002/jhet.5570050205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2‐Quinazolinepropionic acids have been obtained from the reactions of potassium cyanide with o‐carboxy‐ or o‐acyl‐3‐chloropropionanilides. Some of these compounds have been cyclized to pyrrolo [1,2‐a] quinazolines. The reaction of an o‐carbethoxy‐2‐chloroacetanilide with potassium thiocyanate formed a 2‐quinazolinylthioacetic acid, which was cyclized to a thiazolo‐[3,2‐a]quinazoline. A mechanism is presented for the formation of these compounds. Copyright © 1968 Journal of Heterocyclic Chemistry

引用

页码：185 / &