ARYL-HYDROCARBON HYDROXYLASE INDUCIBILITY IS NOT ALTERED IN BLADDER-CANCER PATIENTS OR THEIR PROGENY

被引：9

作者：

PAIGEN, B

WARD, E

STEENLAND, K

HAVENS, M

SARTORI, P

机构：

[1] Department of Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York

[2] Department of Research Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 03期

关键词：

D O I：

10.1002/ijc.2910230307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the possible influence of aryl hydrocarbon hydroxylase (AHH) on susceptibility to bladder cancer in humans. AHH inducibility was measured in the cultured lymphocytes of 16 patients who were being followed after successful treatment for bladder cancer, in 53 progeny of bladder cancer patients, and in matched controls. In both the progeny and patient populations, no evidence was found for a difference between the distribution of AHH inducibility or induced AHH activity compared to the distribution among control individuals. Thus, AHH activity or inducibility does not appear to be a major determinant of bladder cancer risk in humans. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：312 / 315

页数：4

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