220 MHZ PROTON NUCLEAR MAGNETIC RESONANCE STUDY OF GEOMETRIC DISPOSITION OF BASE PAIRS IN OXIDIZED AND REDUCED PYRIDINE NUCLEOTIDES

被引：38

作者：

SARMA, RH

KAPLAN, NO

机构：

[1] Graduate Department of Biochemistry, Brandeis University, Waltham

[2] the Department of Chemistry, University of California, San Diego La Jolla

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(69)90677-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Differential shielding of the symmetrically located C2H and C6H of the pyridine moiety by adenine indicates that the geometric disposition between the pyridine base and the D-ribofuranose ring is syn in α-DPN, β-DPN, β-DPNH, TPNH and the acetylpyridine analog of β-DPNH and anti in the acetylpyridine analogs of β-DPN and TPN. An anti-syn overlap, i.e. adenine is anti and pyridine is syn, is proposed for the stacked conformation of α-DPN, β-DPN, TPN, β-DPNH and the acetylpyridine analog of β-DPNH. An anti-anti overlap is proposed for the stacked conformation in the acetylpyridine analogs of β-DPN and TPN. © 1969.

引用

页码：780 / &

共 8 条

[1]

BENDER C, 1968, FED PROC, V27, P390

[2]

JARDETZK.O, 1966, J BIOL CHEM, V241, P85

[3] NUCLEAR MAGNETIC RESONANCE SPECTRA AND CONFORMATION OF 1,4-DIHYDROPYRIDINES [J].