AGONIST-INDUCED DESENSITIZATION OF BETA-ADRENOCEPTOR FUNCTION IN HUMANS - SUBTYPE-SELECTIVE REDUCTION IN BETA-1-ADRENOCEPTOR OR BETA-2-ADRENOCEPTOR MEDIATED PHYSIOLOGICAL-EFFECTS BY XAMOTEROL OR PROCATEROL

被引：47

作者：

BRODDE, OE

DAUL, A

MICHELREHER, M

BOOMSMA, F

VELD, AJMI

SCHLIEPER, P

MICHEL, MC

机构：

[1] ERASMUS UNIV,HOSP DIJKZIGT,DEPT INTERNAL MED 1,ROTTERDAM,NETHERLANDS

[2] ICI PHARMA DEUTSCHLAND,PLANKSTADT,GERMANY

来源：

CIRCULATION | 1990年 / 81卷 / 03期

关键词：

Lymphocytes; β[!sub]1[!/sub]-adrenoceptors; β[!sub]2[!/sub]-adrenoceptors;

D O I：

10.1161/01.CIR.81.3.914

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effects of β2- (procaterol 2x50 μg/day for 9 days) and β1- (xamoterol 2x200 mg/day for 14 days) adrenoceptor agonists on lymphocyte β2-adrenoceptor density and β1- and β2-adrenoceptor in vivo function (assessed as isoprenaline-infusion-evoked hemodynamic effects and exercise-induced tachycardia) in healthy volunteers. Procaterol decreased lymphocyte β2-adrenoceptor density and all β2-adrenoceptor-mediated in vivo effects but did not affect β1-adrenoceptor-mediated in vivo effects. In contrast, xamoterol neither affected lymphocyte β2-adrenoceptors nor β2-adrenoceptor-mediated in vivo effects but decreased β1-adrenoceptor-mediated in vivo effects. It is concluded that in humans, generally long-term application of β1- or β2-adrenoceptor agonists causes desensitization of β-adrenoceptor function but in a β-adrenoceptor subtype-selective fashion.

引用

页码：914 / 921

页数：8

共 34 条

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