CELLULAR AGING OF RAT FIBROBLASTS INVITRO IS A DIFFERENTIATION PROCESS

被引：73

作者：

KONTERMANN, K ^{[1
]}

BAYREUTHER, K ^{[1
]}

机构：

[1] UNIV HOHENHEIM,INST GENET,D-7000 STUTTGART 70,FED REP GER

来源：

GERONTOLOGY | 1979年 / 25卷 / 05期

关键词：

Biochemical differentiation; Cellular degeneration; Cellular neoplastic transformation; H-1; complex; Morphological differentiation; RNA tumor virus expressions; Stem cell system;

D O I：

10.1159/000212351

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cellular aging of diploid rat fibroblasts in vitro occurs as the result of a three-stage differentiation sequence, taking place in the morphologically recognizable differentiating cell compartment of the fibroblast stem cell system. Simultaneously with an age-dependent morphological differentiation there is an age-dependent biochemical differentiation of the fibroblasts. In cell strains with the genetic background Lewis, the cellular differentiation state, the major histocompatibility complex composition (H-l) and the H-1-complex-controlled expression of endogenous type C viruses determine the ultimate fate of the senescent cell, leading either to cellular degeneration or to cellular neoplastic transformation. © 1979 S. Karger AG, Basel.

引用

页码：261 / 274

页数：14

共 27 条

[1]

BAYREUTHER K, UNPUBLISHED

[2]

Cristofalo Vincent J, 1972, ADV GERONTOL RES, V4, P45

[3] FUNCTIONS OF LYSOSOMES [J].

DEDUVE, C ;

WATTIAUX, R .

ANNUAL REVIEW OF PHYSIOLOGY, 1966, 28 :435-+

[4]

FRIEDENSTEIN AJ, 1974, EXP HEMATOL, V2, P83

[5]

GAJDUSEK DC, 1972, ADV GERONTOL RES, V4, P201

[6] NATURE AND LOCALIZATION OF SV40-INDUCED COMPLEMENT-FIXING ANTIGEN [J].

GILDEN, RV ;

CARP, RI ;

TAGUCHI, F ;

DEFENDI, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 53 (03) :684-&

[7] CORRELATION BETWEEN DEOXYRIBONUCLEIC-ACID EXCISION-REPAIR AND LIFE-SPAN IN A NUMBER OF MAMMALIAN-SPECIES [J].

HART, RW ;

SETLOW, RB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (06) :2169-2173

[8]

HAUSCHKA SD, 1977, CELLULAR SENESCENCE, V1

[9] SERIAL CULTIVATION OF HUMAN DIPLOID CELL STRAINS [J].

HAYFLICK, L ;

MOORHEAD, PS .

EXPERIMENTAL CELL RESEARCH, 1961, 25 (03) :585-+

[10] TESTING COMMITMENT THEORY OF CELLULAR AGING [J].

HOLLIDAY, R ;

HUSCHTSCHA, LI ;

TARRANT, GM ;

KIRKWOOD, TBL .

SCIENCE, 1977, 198 (4315) :366-372

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