INHIBITION OF GROWTH OF RAT HEPATOMA BY LOCAL INJECTION OF LIPOSOMES CONTAINING RECOMBINANT INTERLEUKIN-2 - ANTITUMOR EFFECT OF IL-2 LIPOSOME

被引：24

作者：

KONNO, H

YAMASHITA, A

TADAKUMA, T

SAKAGUCHI, S

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT ANAT 2, HAMAMATSU, SHIZUOKA 431-31, JAPAN

[2] KEIO UNIV, SCH MED, DEPT MICROBIOL, SHINJUKU KU, TOKYO 160, JAPAN

来源：

BIOTHERAPY | 1991年 / 3卷 / 03期

关键词：

ANTITUMOR ACTION; IL-2; LIPOSOME; LOCAL INJECTION; MACROPHAGES;

D O I：

10.1007/BF02171684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human recombinant interleukin-2 (IL-2) was entrapped in liposome, consisting of egg phosphatidylcholine (PC) and cholesterol. The peri-tumor injections of IL-2 liposome inhibited significantly the growth of solid tumor and prolonged the survival time of rats with solid tumors which were induced by a subcutaneous (s.c.) inoculation of AH-66 cells. Immunohistochemical staining of peritoneal exudate cells and tumor tissues revealed a marked accumulation of activated macrophages in and around the tumor tissues induced by the local injections of IL-2 liposome.

引用

页码：211 / 218

页数：8

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