THIACETAZONE - INVITRO ACTIVITY AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS

被引：18

作者：

HEIFETS, LB

LINDHOLMLEVY, PJ

FLORY, M

机构：

[1] National Jewish Center for immunology and Respiratory Medicine, Denver, CO

来源：

TUBERCLE | 1990年 / 71卷 / 04期

关键词：

D O I：

10.1016/0041-3879(90)90043-8

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Bacteriostatic and bactericidal activity of thiacetazone was determined for 68 M. avium clinical isolates and 14 wild drug-susceptible M. tuberculosis strains. The drug had equally low bactericidal activity against both mycobacterial species. The inhibitory activity against most of the M. avium strains was greater than it was against M. tuberculosis. The broth determined MICs for 65 of 68 M. avium strains were between 0.02 and 0.15 μg/ml, while the MICs for M. tuberculosis ranged from 0.08 to 1.2 μg/ml. © 1990.

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页码：287 / 291

页数：5

相关论文

共 24 条

[1] LYSOSOMOTROPIC AGENTS [J].

DEDUVE, C ;

DEBARSY, T ;

POOLE, B ;

TROUET, A ;

TULKENS, P ;

VANHOOF, F .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (18) :2495-+

[2] UBER EINE NEUE, GEGEN TUBERKELBAZILLEN INVITRO WIRKSAME VERBINDUNGSKLASSE [J].

DOMAGK, G .

NATURWISSENSCHAFTEN, 1946, 33 (10) :315-315

[3]

FOX W, 1975, AM REV RESPIR DIS, V111, P325

[4]

GROSSET J, 1970, ADV TUBERC RES, V17, P107

[5] MIC AS A QUANTITATIVE MEASUREMENT OF THE SUSCEPTIBILITY OF MYCOBACTERIUM-AVIUM STRAINS TO 7 ANTITUBERCULOSIS DRUGS [J].

HEIFETS, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (08) :1131-1136

[6] COMPARISON OF BACTERICIDAL ACTIVITIES OF STREPTOMYCIN, AMIKACIN, KANAMYCIN, AND CAPREOMYCIN AGAINST MYCOBACTERIUM-AVIUM AND M-TUBERCULOSIS [J].

HEIFETS, L ;

LINDHOLMLEVY, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (08) :1298-1301

[7] IS PYRAZINAMIDE BACTERICIDAL AGAINST MYCOBACTERIUM-TUBERCULOSIS [J].

HEIFETS, LB ;

LINDHOLMLEVY, PJ .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (01) :250-252

[8] ETHAMBUTOL MICS AND MBCS FOR MYCOBACTERIUM-AVIUM COMPLEX AND MYCOBACTERIUM-TUBERCULOSIS [J].

HEIFETS, LB ;

ISEMAN, MD ;

LINDHOLMLEVY, PJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) :927-932

[9] BACTERICIDAL ACTIVITY INVITRO OF VARIOUS RIFAMYCINS AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS [J].

HEIFETS, LB ;

LINDHOLMLEVY, PJ ;

FLORY, MA .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 141 (03) :626-630

[10]

HEIFETS LB, 1985, ANTIMICROB AGENTS CH, V28, P570, DOI 10.1128/AAC.28.4.570