EFFECT OF TGF-BETA-1, TGF-BETA-2, AND BFGF ON CHICK CARTILAGE AND MUSCLE-CELL DIFFERENTIATION

被引：75

作者：

SCHOFIELD, JN ^{[1
]}

WOLPERT, L ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX HOSP,SCH MED,DEPT ANAT & DEV BIOL,WINDEYER BLDG,CLEVELAND ST,LONDON W1P 6DP,ENGLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1990年 / 191卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0014-4827(90)90048-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In insulin containing defined medium TGF-β1, TGF-β2, and bFGF all stimulate chondrogenic differentiation in high-density micromass cultures of distal limb bud mesenchyme cells of chick embryos. In addition bFGF inhibits myogenic differentiation, while TGF-β1 and TGF-β2 appear to have no effect. TGF-β1 and bFGF together act additively to enhance chondrogenesis, while TGF-β blocks the bFGF inhibitory action on myoblasts, thus allowing them to differentiate. In the absence of insulin, the inhibitory effect of bFGF on muscle cell differentiation is reduced; cartilage differentiation in the presence of the above growth factors is also Slightly reduced. © 1990.

引用

页码：144 / 148

页数：5

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