SOFT-TISSUE REACTION TO COLLAGEN-IMMOBILIZED POROUS POLYETHYLENE - SUBCUTANEOUS IMPLANTATION IN RATS FOR 20 WK

被引：30

作者：

KINOSHITA, Y ^{[1
]}

KUZUHARA, T ^{[1
]}

KIRIGAKUBO, M ^{[1
]}

KOBAYASHI, M ^{[1
]}

SHIMURA, K ^{[1
]}

IKADA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,BIOMED ENGN RES CTR,DEPT BIOMAT,REG MOLEC DESIGN BIOMAT,KYOTO 606,JAPAN

来源：

BIOMATERIALS | 1993年 / 14卷 / 03期

关键词：

COLLAGEN IMMOBILIZATION; POLYETHYLENE; BIOCOMPATIBILITY; TISSUE ADHESION;

D O I：

10.1016/0142-9612(93)90025-W

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Collagen-immobilized porous polyethylene, in which the immobilization was through covalent bonding, and virgin porous polyethylene were implanted subcutaneously in rats from 1 to 20 wk. The results were the ingrowth of the connective tissue into collagen-immobilized porous polyethylene was rich and contained a low level of inflammatory cellular infiltration compared with that of virgin porous polyethylene. The material-tissue interface showed that the living body-originated collagen fibres were firmly anchored into the immobilized collagen layer. These results suggested that covalent immobilization of collagen on to the biomaterial surface is useful in promoting the ingrowth of soft tissue and the tissue adhesion.

引用

页码：209 / 215

页数：7

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