POLYCYSTIC-OVARY-SYNDROME - LOW-DOSE FOLLICLE-STIMULATING-HORMONE ADMINISTRATION IS A SAFE STIMULATION REGIMEN EVEN IN PREVIOUS HYPERRESPONSIVE PATIENTS

被引：17

作者：

DALE, PO

TANBO, T

HAUG, E

ABYHOLM, T

机构：

[1] Department of Gynaecology and Obstetrics, National Hospital, University of Oslo

[2] Hormone Laboratory, Aker Hospital, University of Oslo

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 08期

关键词：

INFERTILITY; LOW-DOSE GONADOTROPIN; POLYCYSTIC OVARY;

D O I：

10.1093/oxfordjournals.humrep.a137797

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We studied 23 women with polycystic ovarian syndrome (PCOS), resistant to clomiphene citrate, who had a previous history of multifollicular ovarian development on gonadotrophin stimulation. Each woman had one cycle of gonadotrophin-stimulating hormone agonist/human menopausal gonadotrophin (GnRHa/HMG) stimulation and then one cycle of low-dose follicle stimulating hormone (FSH) stimulation. All GnRHa/HMG cycles were multifollicular. On the low-dose FSH protocol, 10 cycles were unifollicular, while two to three follicles were observed in nine cycles, and four cycles were multifollicular. The ovarian hyperstimulation syndrome ensued in one of the FSH cycles versus 13 of the GnRHa/HMG cycles. Despite decreasing luteinizing hormone (LH) levels and increasing FSH levels, androgen levels increased during stimulationg on both protocols. There was one pregnancy in the GnRHa/HMG cycles versus six pregnancies following the FSH cycles. In conclusion, low-dose FSH administration seems a safe stimulation regimen with a satisfactory conception rate even in PCOS women with a previous record of multifollicular ovarian development.

引用

页码：1085 / 1089

页数：5

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