A YEAST PROTEIN PHOSPHATASE RELATED TO THE VACCINIA VIRUS VH1 PHOSPHATASE IS INDUCED BY NITROGEN STARVATION

被引：88

作者：

GUAN, K

HAKES, DJ

WANG, Y

PARK, HD

COOPER, TG

DIXON, JE

机构：

[1] WALTHER CANC INST,DEPT BIOL CHEM,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,INST GERONTOL,ANN ARBOR,MI 48109

[3] UNIV TENNESSEE CTR HLTH SCI,DEPT MICROBIOL & IMMUNOL,MEMPHIS,TN 38163

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 24期

关键词：

NITROGEN STARVATION; PHOSPHORYLATION; YVH1; SERUM STIMULATION;

D O I：

10.1073/pnas.89.24.12175

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A phosphatase related to the vaccinia virus VH1 phosphatase has been cloned from Saccharomyces cerevisiae. The yeast phosphatase is related to the Schizosaccharomyces pombe cdc25 gene product and to a protein encoded by a mammalian open reading frame known as 3CH134, which is an immediate early gene responding to serum stimulation. The phosphatase activity of the yeast gene product appears to be restricted to the hydrolysis of phosphotyrosine-containing substrates, whereas the vaccinia phosphatase hydrolyzes both phosphoserine- and phosphotyrosine-containing substrates. The mRNA encoding the yeast phosphatase is dramatically induced by nitrogen starvation. Inactivation of the yeast phosphatase gene results in a decrease in growth rate.

引用

页码：12175 / 12179

页数：5

共 26 条

[1] THE ALLANTOINASE (DAL1) GENE OF SACCHAROMYCES-CEREVISIAE [J].