COMPARATIVE-EVALUATION OF 2 PHARMACEUTICAL BINDERS IN THE WET GRANULATION OF HYDROCHLOROTHIAZIDE LYCATAB(TM) DSH VERSUS KOLLIDON(R)-30

被引：4

作者：

SYMECKO, CW ^{[1
]}

ROMERO, AJ ^{[1
]}

RHODES, CT ^{[1
]}

机构：

[1] PFIZER INC,DEPT CLIN & SCI AFFAIRS,NEW YORK,NY 10017

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 10期

关键词：

D O I：

10.3109/03639049309063007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

LYCATAB(TM**) DSH, a new pharmaceutical binder for the wet granulation process, was compared to KOLLIDON(R) K30, a frequently used povidone binder. Formulations containing 5% binder were prepared under the same processing conditions. Granule, compaction, ejection, and tablet properties, were evaluated to characterize differences between the two binders. Both binders produced end-products of similar quality. The LYCATAB(TM) however, produced a system which exhibited better granule friability, compaction profile, and ejection profile. This indicates that LYCATAB(TM) produced a more robust system when compared to KOLLIDON(R).

引用

页码：1131 / 1141

页数：11

共 12 条

[1] THE EFFECT OF THE BINDING-AGENTS ON THE FRIABILITY AND COMPRESSIBILITY OF GRANULES .1. USING OF THE EQUAL AMOUNTS OF THE BINDING-AGENTS WHICH HAVE DIFFERENT MOLECULAR-WEIGHT [J].