WORKING STANDARDS FOR HEPATITIS-B SURFACE-ANTIGEN FOR USE IN THE UK-BLOOD-TRANSFUSION-SERVICE - RESULTS OF A COLLABORATIVE STUDY

被引：11

作者：

FERGUSON, M ^{[1
]}

PIPKIN, PA ^{[1
]}

HEATH, AB ^{[1
]}

MINOR, PD ^{[1
]}

机构：

[1] NATL INST BIOL STAND & CONTROLS,INFORMAT LAB,POTTERS BAR EN6 3QG,HERTS,ENGLAND

来源：

VOX SANGUINIS | 1993年 / 65卷 / 04期

关键词：

D O I：

10.1111/j.1423-0410.1993.tb02171.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Twenty-six laboratories including 22 Blood Transfusion Centres in England, Scotland, Wales and Northern Ireland participated in a collaborative study to assess the suitability of proposed working standards for hepatitis B surface antigens (HBsAg) for use in the UK Blood Transfusion Service. Data from 88 assays indicated that all laboratories could detect HBsAg in the proposed working standard at a concentration of 0.5 IU/ml. Samples containing HBsAg at a concentration of 0.125 IU/ml were scored positive in 80% of assays and it was concluded that this would be a suitable concentration for inclusion in a monitor sample which would indicate whether the sensitivity of an assay system in routine use is varying over a period of time. The use of a batch of 'provisional' working standard tested under field conditions over a period of 4 months has been monitored. HBsAg was not detected in only 2 out of 6,523 assays.

引用

页码：303 / 308

页数：6