MOLECULAR CLONES OF THE P58 NK CELL-RECEPTOR REVEAL IMMUNOGLOBULIN-RELATED MOLECULES WITH DIVERSITY IN BOTH THE EXTRACELLULAR AND INTRACELLULAR DOMAINS

被引：559

作者：

WAGTMANN, N

BIASSONI, R

CANTONI, C

VERDIANI, S

MALNATI, MS

VITALE, M

BOTTINO, C

MORETTA, L

MORETTA, A

LONG, EO

机构：

[1] IST NAZL RIC CANC,I-16132 GENOA,ITALY

[2] UNIV GENOA,IST ISTOL & EMBRIOL GEN,I-16132 GENOA,ITALY

来源：

IMMUNITY | 1995年 / 2卷 / 05期

关键词：

D O I：

10.1016/1074-7613(95)90025-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Crosslinking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning of the p58 NK receptor reported here revealed a new member of the immunoglobulin superfamily. Five distinct p58 receptors, with sequence diversity in the immunoglobulin-related domains, were identified in a single individual. All NK clones tested expressed at least one p58 member. Three different types of transmembrane and cytoplasmic domains exist, even among receptors with closely related extracellular domains. These data revealed a repertoire of NK cells with clonally distributed p58 receptors exhibiting diversity in both extracellular and intracellular domains.

引用

页码：439 / 449

页数：11

共 43 条

[1] Bezouska, Yuen, O'Brien, Childs, Chai, Lawson, Drbal, Fiserova, Pospisil, Feizi, Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity, Nature, 372, pp. 150-157, (1994)
[2] Biassoni, Verdiani, Cambiaggi, Romeo, Ferrini, Moretta, Human CD3−CD16+ natural killer cells express the hGATA3 T cell transcription factor and an unrearranged 2.3-kb TCR delta transcript, Eur. J. Immunol., 23, pp. 1083-1087, (1993)
[3] Bottino, Vitale, Olcese, Sivori, Morelli, Augugliaro, Ciccone, Moretta, Moretta, The human natural killer cell receptor for major histocompatibility complex class I molecules: surface modulation of p58 molecules and their linkage to CD3 zeta chain, FcepsilonRI gamma chain and the p56lck kinase, European Journal of Immunology, 24, pp. 2527-2534, (1994)
[4] Chomczynski, Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162, pp. 156-159, (1987)
[5] Ciccone, Pende, Vials, Di Donato, Tripodi, Orengo, Guardiola, Moretta, Moretta, Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans, J. Exp. Med., 175, pp. 709-718, (1992)
[6] Ciccone, Pende, Vials, Than, Di Donato, Orengo, Biassoni, Verdiani, Amoroso, Moretta, Moretta, Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2), J. Exp. Med., 176, pp. 963-971, (1992)
[7] Ciccone, Pende, Vitale, Nanni, Di Donato, Bottino, Morelli, Vials, Amoroso, Moretta, Moretta, Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells, Eur. J. Immunol., 24, pp. 1003-1006, (1994)
[8] Colonna, Borsellino, Falco, Ferrara, Strominger, HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells, Proc. Natl. Acad. Sci. USA, 90, pp. 12000-12004, (1993)
[9] Correa, Raulet, Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells, Immunity, 2, pp. 61-71, (1995)
[10] Correa, Corral, Raulet, Multiple natural killer cell-activating signals are inhibited by major histocompatibility complexclass I expression in target cells, Eur. J. Immunol., 24, pp. 1323-1331, (1994)

← 1 2 3 4 5 →