REGRESSION OF EXPERIMENTAL HUMAN LEUKEMIAS AND SOLID TUMORS INDUCED BY EPSTEIN-BARR VIRUS-IMMORTALIZED B-CELLS

被引：15

作者：

ANGIOLILLO, AL ^{[1
]}

SGADARI, C ^{[1
]}

SHEIKH, N ^{[1
]}

REAMAN, GH ^{[1
]}

TOSATO, G ^{[1
]}

机构：

[1] CHILDRENS NATL MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 19卷 / 3-4期

关键词：

EPSTEIN-BARR VIRUS; TUMOR REGRESSION; SOLID TUMORS; LEUKEMIA;

D O I：

10.3109/10428199509107897

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously have reported on an experimental athymic mouse model in which regression of human Burkitt's lymphoma is induced by either coinjection with or intratumor inoculation of Epstein-Barr virus (EBV)-immortalized human B cells, In the current study, we were interested in determining whether the powerful antitumor effects of EBV-immortalized B cells could be effective against a variety of human tumors grown in athymic mice, including acute lymphocytic leukemia, malignant melanoma, acute promyelocytic leukemia, neuroblastoma, lung carcinoma, colon adenocarcinoma, Wilms tumor, Hodgkin's lymphoma, rhabdomyosarcoma and breast adenocarcinoma. We report here the results of experiments in nude mice that demonstrated the potent antitumor effect of EBV-immortalized B cells against human tumors derived from a variety of different tissues.

引用

页码：267 / 276

页数：10

共 19 条

[1]

Tosato G., Sgadari C., Taga K., Jones K., Pike S., Rosenberg A., Sechler J., Magrath I., Love L., Bhatia K., Regression of experimental Burkitt's lymphoma induced by Epstein Barr virus-immortalized human B cells, Blood, 83, pp. 776-784, (1994)

[2]

Nilsson K., Klein G., Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt's lymphoma, Advances in Cancer Res., 37, pp. 319-380, (1982)

[3]

Gurtsevitch V.E., O'Conor G.T., Lenoir G.M., Burkitt's lymphoma cell lines reveal different degrees of tumorigenicity in nude mice, Internatl, J. Cancer, 41, pp. 87-95, (1988)

[4]

Tosato G., Blaese R.M., Yarchoan R., Relationship between immunoglobulin production and immortalization by Epstein-Barr virus, J Immunol., 135, pp. 959-964, (1985)

[5]

Shiramizu B., Barriga F., Neequaye J., Jafri A., Dalla-Favera R., Nieri A., Guttierez M., Levine P., Magrath I., Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: relevance to geography and Epstein-Barr virus association, Blood, 77, pp. 1516-1526, (1991)

[6]

Folkman J., Tumor angiogenesis, Advances in Cancer Res., 43, pp. 175-203, (1985)

[7]

Folkman J., Shing Y., Angiogenesis, J. Biological Chem., 267, 16, pp. 10931-10934, (1992)

[8]

O'Reilly M., Holmgren L., Sing Y., Chen C., Rosenthal R., Moses M., Lane W., Cao Y., Sige H., Acid Folkman J., Angiostatin: a novel angiogenesis inhibitor that mediates the sup pression of metastases by Lewis lung carcinoma, Cell, 79, pp. 315-328, (1994)

[9]

Muller G., Behrens J., Nussbaumer U., Bohlen P., Birchmeier W., Inhibitory action of transforming growth factor b on endothelial cells, Proc. Natl. Acad Sci., 84, pp. 5600-5604, (1987)

[10]

Good D.J., Polverini P., Rastinejad F., Le Beau M.M., Lemons R.S., Frazier W.A., Bouck N.P., A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin, Proc. Natl. Acad. Sci., 87, pp. 6624-6628, (1990)

← 1 2 →