PROPHYLAXIS AND THERAPY WITH FACTOR-VII CONCENTRATE (HUMAN) IMMUNE, VAPOR HEATED IN PATIENTS WITH CONGENITAL FACTOR-VII DEFICIENCY - A SUMMARY OF CASE-REPORTS

被引:29
作者
COHEN, LJ
MCWILLIAMS, NB
NEUBERG, R
ZINKHAM, W
BAUER, K
GRIBBLE, TJ
GLOWALLA, MB
BORSON, R
PHILLIPS, MD
KUNSCHAK, M
机构
[1] IMMUNO AG WIEN,CLIN RES MANAGEMENT,A-1220 VIENNA,AUSTRIA
[2] MAINE MED CTR,MAINE CHILDRENS CANC PROGRAM,PORTLAND,ME 04102
[3] MAINE MED CTR,DEPT PEDIAT,PORTLAND,ME 04102
[4] EASTERN MAINE MED CTR,BANGOR,ME
[5] CHILDRENS HOSP,CTR CANC & BLOOD DISORDERS,DEPT PEDIAT,COLUMBIA,SC
[6] JOHNS HOPKINS UNIV HOSP,BALTIMORE,MD 21287
[7] BETH ISRAEL HOSP,DIV HEMATOL ONCOL,BOSTON,MA 02215
[8] UNIV NEW MEXICO,TED R MONTOYA HEMOPHILIA PROGRAM,ALBUQUERQUE,NM 87131
[9] KAISER PERMANENTE MED CTR,LOS ANGELES,CA 90034
[10] UNIV WASHINGTON,SCH MED,ST LOUIS,MO
[11] UNIV TEXAS,HLTH SCI CTR,HOUSTON MED SCH,HOUSTON,TX
关键词
PROCONVERTIN DEFICIENCY; SERUM PROTHROMBIN CONVERSION ACCELERATOR DEFICIENCY; HEMOPHILIA;
D O I
10.1002/ajh.2830500408
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hereditary factor VII deficiency is a rare autosomal recessive condition, usually associated with normal or reduced levels of a functionally defective molecule, The available means of treating this condition in North America presents serious health risks to the patient, Transfusion with fresh frozen plasma carries a risk of volume overload and a significant risk for viral transmission, Sustained prothrombin complex therapy is associated with a high risk for thrombogenic complications. This communication describes the use of Factor VII Concentrate (Human) Immune, Vapor Heated-an intermediate purity factor VII concentrate from Immune A.G.-for the treatment of 13 patients with factor VII deficiency, Treatment regimens described include those for long-term prophylaxis (three children), acute hemorrhages (two children, one adult), peripartum prophylaxis (one patient), and surgical coverage (two children, four adults), Prophylaxis and therapy were successful in all cases, the medication was well-tolerated, and there were no complications, In the three cases of longterm prophylaxis in children, doses of 10-50 IU/kg were given one to three times a week; one patient has undergone long-term prophylaxis for approximately 8 years, one patient for 1 year, and one patient for 11/2 years. Three cases in which Factor VII Concentrate was principally used for treatment of acute episodes of bleeding are described, One infant received Factor VII Concentrate on about 50 occasions for treatment of mucosal bleeding; a correction to 40-100% resulted in cessation of bleeding within 15 min in all cases. For treatment of an episode of intracranial bleeding, an 8-year-old boy received a dose of 37 IU/kg Factor VII Concentrate every 6 hr for peak factor VII levels of approximately 100% and troughs as low as 4% over the 11-day treatment period, A 37-year-old adult male with intracranial bleeding received alternating doses of 16 IU/kg and 8 IU/kg every 6 hr for 10 days with peak factor VII levels in the upper thirties (%), The peak favor VII level during surgical coverage with Factor VII Concentrate (neurosurgery, open reduction of ankle bones, dental surgery, pituitary adenoma surgery, closed liver biopsy) was approximately 100% in all cases, with trough levels ranging from 8 to 65% over treatment periods of 24 hr to 16 days using treatment intervals of 6-12 hr. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:269 / 276
页数:8
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