AUTOMATED ASSAY OF SINGLE TABLETS OF DIGOXIN

被引：16

作者：

MYRICK, JW

机构：

[1] U S Department of Health, Education and Welfare, Food and Drug Administration, National Center for Drug Analysis, St Louis, Missouri

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 08期

关键词：

Automated procedure–digoxin; single tablets; Colorimetric analysis–spectrophotometer; Diagram‐automated analysis; digoxin; Digoxin tablets–analysis;

D O I：

10.1002/jps.2600580828

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An automated analytical system has been used to determine the amount of digoxin in single tablets at a level of 0.25 mg. per tablet. The active ingredient in an alcoholic solution was oxidized with periodate; after removal of the excess periodate with arsenite, reaction with 2‐thiobarbituric acid at 75° produced a visible color which was recorded from a colorimeter. Interference by dextrose, which may be present in the tablet, was eliminated by simultaneous determination at a different wavelength. Relative standard deviation of the method was 0.7% for powdered tablet samples and 1.0% for an authentic tablet formulation. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1018 / &

共 14 条

[1] BALJET H, 1918, SCHWEIZ APOTHEKER ZT, V56, P71
[2] BALJET H, 1918, SCHWEIZ APOTHEK ZTG, V56, P84
[3] THE QUANTITATIVE ESTIMATION OF DIGITALIS GLYCOSIDES BY MEANS OF KELLER-KILIANI AND PESEZ-DEQUEKER REAGENTS
DEQUEKER, R
LOOBUYCK, M
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1955, 7 (08) : 522 - 526
[4] THE ANALYSIS OF DIGOXIN PREPARATIONS
HOUK, AEH
ALEXANDER, TG
BANES, D
[J]. JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1959, 48 (04): : 217 - 218
[5] JAMES AE, 1947, J AM PHARM ASSOC SCI, V36, P1
[6] KHOURY AJ, 1967, AUTOMATION ANAL CHEM, V1, P192
[7] MESNARD P, 1961, CR HEBD ACAD SCI, V253, P497
[8] PESEZ M, 1952, Ann Pharm Fr, V10, P104
[9] COLORIMETRIC ESTIMATION OF DIGITALIS GLYCOSIDES WITH 2,4-DINITRODIPHENYLSULPHONE
TATTJE, DHE
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1958, 10 (08) : 493 - 498
[10] TATTJE HE, 1957, J PHARM PHARMACOL, V9, P29

← 1 2 →