DIRECTED REGIOCHEMICAL CONTROL IN THE RING EXPANSION REACTIONS OF A SUBSTITUTED TRANS-DECALONE

被引:16
作者
AUBE, J
HAMMOND, M
机构
[1] Department of Medicinal Chemistry, The University of Kansas, Lawrence
关键词
D O I
10.1016/S0040-4039(00)88999-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A derivative of the Wieland-Miescher ketone can selectively be converted into either regioisomeric ring-expanded lactam. The synthesis of the diastereomeric N-α-methylbenzyl oxaziridine derivatives determines the regiochemistry of the product lactam and additionally allows the separation of a racemic substrate into regio- and enantioisomeric lactams. © 1990.
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页码:2963 / 2966
页数:4
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