ANALYSIS OF MEGAKARYOCYTE PLOIDY IN PATIENTS WITH THROMBOCYTOSIS

被引：16

作者：

KANZ, L

HOLLEN, C

FRIESE, P

BURSTEIN, SA

机构：

[1] UNIV FREIBURG,MED KLIN,DEPT HEMATOL & ONCOL,W-7800 FREIBURG,GERMANY

[2] UNIV OKLAHOMA,HLTH SCI CTR,ST FRANCIS MED RES INST,OKLAHOMA CITY,OK 73190

来源：

INTERNATIONAL JOURNAL OF CELL CLONING | 1990年 / 8卷 / 04期

关键词：

Flow cytometry; Megakaryocytes; Myeloproliferative disorders; Ploidy; Thrombocytosis;

D O I：

10.1002/stem.5530080415

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The DNA content of bone marrow megakaryocytes was analyzed in 24 patients with myeloproliferative disorders, 23 patients with secondary thrombocytosis and 15 normal volunteers using 2‐color flow cytometry. Compared with normal controls, the majority of patients with secondary thrombocytosis, polycythemia vera and essential thrombocytosis exhibited a relative increase in higher ploidy (> 16N) cells. In contrast, patients with chronic myelogenous leukemia exhibited an increase in lower ploidy cells (< 16N), with a modal DNA content of 8N. Patients with myeloproliferative disorders tended to show a decrease in the 16N megakaryocyte population compared with patients with secondary thrombocytosis. No correlation between ploidy distribution and platelet count was observed. Copyright © 1990 AlphaMed Press

引用

页码：299 / 306

页数：8

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